An interventional study of Whiteness HP 35% and Whiteness HP 35% + LASER in Pulp Inflammation, sponsored by Universidade Federal do Para. Completed at 1 site in Brazil. Open to participants aged 20 Years to 26 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-09-14.
Sponsored by Universidade Federal do Para · Not applicable, Interventional, and Treatment
This randomized, controlled, blinded clinical trial evaluated the effectiveness of different desensitizing protocols in preventing pulp inflammation after bleaching treatment with 35% hydrogen peroxide (PH) (Whiteness PH 35%).
Thirty healthy third human molars extracted by orthodontic indication were randomized and allocated into five groups (n = 6): CN (negative control): without intervention; CP (Positive control): PH; PMB: PH + photobiomodulation with low power laser; CPP: PH + casein phosphopeptide phosphopeptide amorphous calcium phosphate (CPP-ACPF); NANO: PH + nanohydroxyapatite. The office whitening was performed in two sessions with a single application of 45 min and an interval of 48 hours between them. Pulp tissues were removed for immunohistochemical analysis. Immunostaining was performed for Caspase 3 using an Axio Scope.A1 microscope.
3,438 studies on the registry are indexed under Inflammation; 629 are open to participants now.
This study's enrollment of 18 is below the median of 50 across 2,436 interventional studies indexed under Inflammation.
Browse Inflammation studies →Universidade Federal do Para is the lead sponsor of 29 studies on the registry; 4 are open to participants now.
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Exclusion criteria:
Whiteness HP 35%
Other: Whiteness HP 35%
Whiteness HP 35% + Laser
Other: Whiteness HP 35% · Device: Whiteness HP 35% + LASER
Whiteness HP 35% + CPP
Other: Whiteness HP 35% · Other: Whiteness HP 35% + CPP
Whiteness HP 35% + NANO
Other: Whiteness HP 35% · Other: Whiteness HP 35% + NANO
Without intervention
Single application of 45 minutes on the buccal surfaces of third molars, with an average thickness of 1 mm
A dose of LASER (60 J / cm2, for 16 seconds) was applied at two points, one point in the cervical region and another in the center of the buccal surface of the third molars, using visible infrared LASER therapy (Photon III / DMC, São Carlos, SP, Brazil), with a wavelength of 808 nm, and AsGaAl, as an active medium.
Topical application of casein phosphopeptide amorphous calcium phosphate fluoride CPP-ACPF (My Paste Plus, Recaldent, GC, USA) with the aid of a microbrush (KG Sorensen, SP, Brazil) in a passive way for 5 minutes.
A topical application of nanohydroxyapatite (Nano P FGM, SC, Brazil) was performed with the aid of a microbrush (KG Sorensen, SP, Brazil) in a passive way for 5 minutes after teeth whitening.
Pulp inflammation
Evaluation of pulp inflammation through immunohistochemistry of the third molar whitening or not
Time frame: 3 days After extraction of third molars
This study is completed, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.
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Universidade Federal do Para