An interventional study of Mesenteric sparing ileocolic resection and Central mesenterectomy ileocolic resection in Crohn's Disease, sponsored by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA). Completed at 1 site in Netherlands. Open to participants aged 16 Years and older. Per ClinicalTrials.gov, last updated 2023-12-26.
Sponsored by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Not applicable, Interventional, and Treatment
The aim of this multicenter randomised controlled trial is to analyse the six month endoscopic recurrence following a mesenteric sparing versus a central mesenterectomy performing an ileocolic resection for CD.
There is emerging evidence to suggest that Crohn's disease (CD) may be a disease of the mesentery rather than just of the bowel alone. A more extensive central mesenterectomy (up to the level of the ileocolic artery), in order to remove an increased volume of affected mesentery to prevent postoperative CD, has been suggested to lead to beneficial results. It is hypothesised that patients who undergo a central mesenterectomy during an ileocolic resection compared to a mesenteric sparing ileocolic resection will have decreased recurrence rates.
1,880 studies on the registry are indexed under Crohn Disease; 462 are open to participants now.
This study's enrollment of 139 is above the median of 66 across 1,188 interventional studies indexed under Crohn Disease.
Browse Crohn Disease studies →Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) is the lead sponsor of 512 studies on the registry; 178 are open to participants now.
Counted across the registry records on this site, refreshed daily.
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
Exclusion Criteria:
A potential subject who meets any of the following criteria will be excluded from participation in this study:
Standard procedure for CD, ileocolic resection without removal of the mesentery.
Procedure: Mesenteric sparing ileocolic resection
Experimental procedure for CD: ileocolic resection in which the mesentery is taken up to the level of the ileocolic trunc.
Procedure: Central mesenterectomy ileocolic resection
Mesentery left in situ
Mesentery is taken up to the level of the ileocolic trunk
The post-operative endoscopic recurrence of Crohn's disease at six months following ileocolic resection
Time frame: 6 months after surgery
Postoperative morbidity
Number of patients with Postoperative morbidity
Time frame: 30 days after surgery
Clinical recurrence rate following ileocolic resection
Number of patients with Clinical recurrence rate following ileocolic resection
Time frame: 1 year after surgery
The need for restarting immunosuppressive medication within the first year postoperatively for endoscopic or clinical recurrence
.The need for restarting immunosuppressive medication within the first year postoperatively for endoscopic or clinical recurrence
Time frame: 1 year after surgery
The 5 year reoperation rate for recurrence of disease at the anastomotic site.
The 5 year reoperation rate for recurrence of disease at the anastomotic site.
Time frame: 5 years
Documents are hosted by the registry — open the source record to download them.
Plan to share: No
This study is completed, as verified in Dec 2023. You cannot join it, but the record below documents what was studied.
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Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)