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Enrolling by invitationNCT04520347IVTCCUpdated Dec 15, 2025

IVTCC 2.0: A Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry

An observational study in Ventricular Arrhythmia, Ventricular Tachycardia and Premature Ventricular Contraction (PVC), sponsored by University of California, Los Angeles. Enrolling by invitation at 41 sites in 7 countries. Per ClinicalTrials.gov, last updated 2025-12-15.

Sponsored by University of California, Los Angeles · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
10,000
Sex
All
01

Study summary

This is a prospective multi-center international registry. The objective of this registry is to collect prospective data on patients undergoing catheter ablation for Ventricular Tachycardia (VT) and Premature Ventricular Contractions (PVC). The registry will be used for clinical monitoring, research, and quality improvement purposes.

Read the detailed description

Sudden cardiac death (SCD), predominantly due to ventricular tachyarrhythmias, is a leading cause of mortality in the United States and around the world. Catheter ablation of ventricular arrhythmias has proven efficacious in reducing the burden of arrhythmias and reducing implantable cardiac defibrillator (ICD) shocks.

The aim of this study is to create a prospective international database registry that will allow for better assessment of the outcomes of catheter ablation of ventricular arrhythmias. The registry, with approximately 30 participating centers, will help to identify the overall success rates and associated benefits of the procedure and provide more comprehensive data on understudied populations and treatment.

02

Conditions studied

  • Ventricular Arrhythmia
  • Ventricular Tachycardia
  • Premature Ventricular Contraction (PVC)
  • Cardiomyopathy

Keywords

  • Arrhythmia
  • Cardiac Conduction System Disease
  • Sudden Cardiac Death
  • Implantable Cardiac Defibrillator (ICD)
03

In context

Tachycardia, Ventricular

451 studies on the registry are indexed under Tachycardia, Ventricular; 120 are open to participants now.

This study's planned enrollment of 10,000 is above the median of 167 across 147 observational studies indexed under Tachycardia, Ventricular.

Browse Tachycardia, Ventricular studies →

Lead sponsor

University of California, Los Angeles is the lead sponsor of 1,170 studies on the registry; 195 are open to participants now.

Of its 95 completed or terminated interventional studies of FDA-regulated products, 70 (74%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with ventricular arrhythmias that undergo catheter ablation for ventricular tachycardia or premature ventricular contractions.

Eligibility criteria

Inclusion Criteria:

- All patients undergoing catheter ablation for ventricular tachycardia (VT) or premature ventricular contractions (PVCs).

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
10,000 participants (estimated)
Target follow-up
10 Years
Patient registry
Yes
06

What researchers measure

Primary outcomes

  1. Ventricular tachycardia (VT) recurrence

    Freedom from ventricular tachycardia episodes requiring ICD Intervention (shock or Anti-Tachycardia Pacing) or repeat procedure.

    Time frame: From date of procedure assessed by shock, Anti-Tachycardia Pacing, or repeat procedure, up to 10 years.

Secondary outcomes

  1. Rate of complications

    Cardiovascular-related and procedure-related major complications and/or adverse events.

    Time frame: From date of procedure assessed up to 12 months.

  2. Time to transplant or death

    Time frame: From date of procedure assessed by date of transplant and/or death, up to 10 years.

07

Study locations

41 sites
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 15, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04520347
Responsible party
Jason Bradfield, MD (Director, Specialized Program for Ventricular Tachycardia, University of California, Los Angeles) — Principal investigator
First posted
Aug 20, 2020
Start date
Dec 1, 2018
Primary completion
Dec 2026 (estimated)
Completion
Nov 2027 (estimated)
Last update
Dec 15, 2025

Study contacts

Jason Bradfield, MD
principal investigator · University of California, Los Angeles
Kalyanam Shivkumar, MD, PhD
study chair · University of California, Los Angeles
Paolo Della Bella, MD
study chair · San Raffaele Hospital, Italy
Francis Marchlinski, MD, FACC, FAHA, FHRS
study chair · University of Pennsylvania Health System
Andrea Natale, MD, FACC, FHRS, FESC
study chair · Texas Cardiac Arrhythmia Institute at St. David's Medical Center
William G Stevenson, MD
study chair · Vanderbilt Heart and Vascular Institute

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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