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CompletedNCT04508478ExAFUpdated Sep 21, 2026

Exercise Training to Atrial Fibrillation

An interventional study of Aerobic training and Resistance training in Atrial Fibrillation, sponsored by National Taiwan University Hospital. Completed at 1 site in Taiwan. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-09-21.

Sponsored by National Taiwan University Hospital · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
8
Allocation
Randomized
Ages
18 Years to 90 Years
Sex
All
01

Study summary

To test the impacts of different exercise training programs to the cardiopulmonary function, muscle metabolism, and body mass composition

Read the detailed description

Atrial fibrillation (AF) has been a global threat due to its increasing incidence and prevalence, and also its potential complications of embolic stroke and heart failure, and therefore has a great impact on life expectancy and quality of life. AF with preserved ventricular function is associated with exercise intolerance, and the effect of physical training had shown to improve life quality and heart function in the population. However, the optimal physical training modalities and intensities are not well studies.

Here we conduct a prospective, randomized, and interventional trial to investigate the effects of different exercise training programs to the burden of AF. We also exploit advanced imaging modalities, including dual x-ray absorptiometry and muscle magnetic resonance, to explore the change of body mass compositions. With this project, we will be able to explore the effects of different physical exercise modalities to the burden of AF and heart function, and also build up a best exercise training program, specific for this population.

02

Conditions studied

  • Atrial Fibrillation

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Keywords

  • Atrial Fibrillation
  • weight training
  • aerobic training
  • cardio-pulmonary function
03

In context

Atrial Fibrillation

3,870 studies on the registry are indexed under Atrial Fibrillation; 924 are open to participants now.

This study's enrollment of 8 is below the median of 144 across 2,380 interventional studies indexed under Atrial Fibrillation.

Browse Atrial Fibrillation studies →

Lead sponsor

National Taiwan University Hospital is the lead sponsor of 2,563 studies on the registry; 569 are open to participants now.

Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  1. Paroxysmal or persistent atrial fibrillation
  2. Daily activity below moderate intensity \< 300 minutes or high intensity \< 150 minutes per week.

Exclusion criteria

Exclusion Criteria:

  1. Active infection.
  2. Implant cardiac pacemaker.
  3. Uncontrolled hypertension.
  4. Cardiopulmonary contraindication to exercise training, such as decompensated heart failure, acute pulmonary edema, unstable angina, uncontrolled arrhythmia causing hemodynamic compromise, symptomatic severe aortic stenosis, suspected dissecting aortic aneurysm, severe pulmonary hypertension, acute myocarditis, endocarditis or pericarditis, uncontrolled asthma and SpO2 \< 90% at rest on room air.
  5. Inability to follow verbal command or to walk on treadmill or use stationary bike.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
8 participants (actual)

Study arms

  • Experimental
    Aerobic training

    Behavioral: Aerobic training

  • Active comparator
    Resistance training

    Behavioral: Resistance training

  • Placebo comparator
    Control

    Behavioral: Control physical exercise

Interventions

  • BehavioralAerobic training

    Aerobic training

  • BehavioralResistance training

    Resistance training

  • BehavioralControl physical exercise

    Control physical exercise

06

What researchers measure

Primary outcomes

  1. AF burden

    AF burden on 14 day ECG

    Time frame: 5 months

  2. CPET/6 minute walking test

    CPET/6 minute walking test

    Time frame: 5 months

  3. DEXA/muscle MRI

    DEXA/muscle MRI

    Time frame: 5 months

07

Study locations

1 site
  • National Taiwan University Hospital
    Taipei, Taiwan
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 21, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04508478
Lead sponsor
National Taiwan University Hospital
Responsible party
Sponsor
First posted
Aug 11, 2020
Start date
Nov 3, 2021
Primary completion
Dec 31, 2024
Completion
Jun 26, 2026
Last update
Sep 21, 2026

Study contacts

Chih-Chieh Yu, MD.PhD
principal investigator · National Taiwan University Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

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