An observational study in Paroxysmal Atrial Fibrillation, sponsored by Poitiers University Hospital. Completed at 1 site in France. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2025-12-24.
Sponsored by Poitiers University Hospital · Observational
Atrial fibrillation is the most common arrhythmia. The posterior surface of the left atrium is covered by an extensive network belonging to the autonomic nervous system that can be damaged during the ablation. The involvement of the autonomous nervous system in the genesis and maintenance of atrial fibrillation remains poorly understood. Baroreflex sensitivity is a non-invasive method assessing autonomous nervous system activity.
The rate of atrial fibrillation recurrence after ablation is currently high and a better understanding of the mechanisms associated with recurrence is essential to improve selection of the patients who will benefit the most from this procedure.
The aim of this study is to evaluate the association between the baroreflex sensitivity and atrial fibrillation recurrences and to analyze the prognostic contribution of the baroreflex measurement compared to other published criteria.
3,870 studies on the registry are indexed under Atrial Fibrillation; 924 are open to participants now.
This study's enrollment of 116 is below the median of 300 across 1,363 observational studies indexed under Atrial Fibrillation.
Browse Atrial Fibrillation studies →Poitiers University Hospital is the lead sponsor of 310 studies on the registry; 64 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients with paroxysmal atrial fibrillation undergoing atrial fibrillation ablation
Exclusion Criteria:
pulmonary vein isolation : cryoablation or radiofrequency
Mean slope assessed before ablation in the recurrence and the non-recurrence groups
To compare baroreflex sensitivity assessed by mean Slope 1 month before the ablation in the recurrence group at 1 year and in the no AF recurrence group at 1 year.
Time frame: Recurrence is assessed at one year of follow-up
Association between baroreflex sensitivity assessed before ablation and atrial fibrillation burden
Association between baroreflex sensitivity evaluated by mean slope, LF gain and HF gain 1 month before AF ablation and AF burden after 1 year of follow-up;
Time frame: Burden is assessed at one year of follow-up
Baroreflex sensitivity fall between the groups with and without AF recurrence
To compare the baroreflex sensitivity fall between before and day1 of ablation between the groups with and without AF recurrence at 1 year follow-up ;
Time frame: Recurrence is assessed at one year of follow-up
Evolution of baroreflex sensitivity
To describe the evolution of baroreflex sensitivity in the group with and in the group without recurrence.
Time frame: Before, day 1 and month 3 after the ablation
Biological and imaging parameters
To look for an association between biological and imaging parameters and atrial fibrillation burden at 1 year.
Time frame: Burden is assessed at one year of follow-up
Quality of life
To compare quality of life before and at one year after atrial fibrillation ablation in patients with and without AF recurrence;
Time frame: before and at one year after atrial fibrillation ablation
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Poitiers University Hospital