ClinicalTrials.gg
CompletedNCT04424979Updated Oct 6, 2026

Feasibility Tests for Various Prism Configurations for Visual Field Loss

An interventional study of High power prisms in Hemianopia, Homonymous, Tunnel Vision and Visual Field Defect, Peripheral, sponsored by Massachusetts Eye and Ear Infirmary. Completed at 1 site in United States. Open to participants aged 7 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-10-06.

Sponsored by Massachusetts Eye and Ear Infirmary · Not applicable, Interventional, and Device feasibility

Updated Oct 6, 2026Now CompletedPrimary completion moved+2 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Not applicable
Ages
7 Years to 80 Years
Sex
All
01

Study summary

The investigators will develop and test different configurations of high-power prisms to expand the field of vision of patients with visual field loss to assist them with obstacle detection when walking. The study will involve multiple visits (typically four) to Schepens Eye Research Institute for fitting and testing with the prism glasses. The overall objective is to determine best designs and fitting parameters for implementation in prism devices for future clinical trials.

02

Conditions studied

  • Hemianopia, Homonymous
  • Tunnel Vision
  • Visual Field Defect, Peripheral
  • Visual Field Constriction Bilateral
  • Visual Field Defect Homonymous Bilateral

Browse trials for

Keywords

  • Visual field expansion
  • Prisms
  • Hemianopsia
  • Tunnel vision
  • Visual field loss
03

In context

Hemianopsia

63 studies on the registry are indexed under Hemianopsia; 24 are open to participants now.

This study's enrollment of 10 is below the median of 32 across 53 interventional studies indexed under Hemianopsia.

Browse Hemianopsia studies →

Lead sponsor

Massachusetts Eye and Ear Infirmary is the lead sponsor of 100 studies on the registry; 23 are open to participants now.

Of its 13 completed or terminated interventional studies of FDA-regulated products, 7 (54%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
7 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Visual field loss, either peripheral field loss or hemianopic field loss
  • Visual acuity of at least 20/50 in the better eye
  • In sufficiently good health to be able to complete sessions lasting 2-4 hours
  • Able to independently walk short distances
  • Able to give voluntary,
  • Able to speak English

Exclusion criteria

Exclusion Criteria:

  • Any physical or mental impairments, including cognitive dysfunction, balance problems or other deficits that could impair the ability to walk or use the prism spectacles
  • A history of seizures in the last 6 months
  • Hemispatial neglect (subjects with hemianopic field loss only)
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Device feasibility
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
10 participants (actual)

Study arms

  • Experimental
    High power prisms

    Various configurations of high power prisms will be developed for each individual and custom fit into spectacles lenses.

    Device: High power prisms

Interventions

  • DeviceHigh power prisms

    High power prisms designed to shift images from blind areas into portions of the wearer's remaining, seeing, field of vision

06

What researchers measure

Primary outcomes

  1. Field of view expansion

    Horizontal and vertical extent of the expansion (in degrees) of the field of view

    Time frame: Through study completion, an average of four months

Secondary outcomes

  1. Pedestrian detection rate

    Proportion of pedestrians detected (in simulated walking or simulated driving)

    Time frame: Through study completion, an average of four months

07

Study locations

1 site
  • Schepens Eye Research Institute
    Boston, Massachusetts 02114, United States
08

References and documents

Publications

  • Bowers AR, Manda S, Shekar S, Hwang AD, Jung JH, Peli E. Pilot study of a pedestrian collision detection test for a multisite trial of field expansion devices for hemianopia. Optom Vis Sci. 2024 Jun 1;101(6):408-416. doi: 10.1097/OPX.0000000000002152. PubMed 38990239 ↗

Individual participant data

Plan to share: No

09

Updates

1 registry update since Sep 25, 2026
Status
Recruiting→Completed
changed Oct 6, 2026
Primary completion
Aug 2026→Jun 30, 2026 (actual)
Oct 6, 2026
Study completion
Dec 2026→Sep 30, 2026 (actual)
Oct 6, 2026
Enrollment
20 (estimated)→10 (actual)
Oct 6, 2026
Show all 1 update
  1. Oct 6, 2026
    Recruiting→Completed
    Primary completion Aug 2026→Jun 30, 2026 (now actual)
    Study completion Dec 2026→Sep 30, 2026 (now actual)
    Enrollment 20 (estimated)→10 (actual)
    + 3 other changes: verification date, contact details and site details

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT04424979
Responsible party
Alexandra Bowers (Associate Professor, Massachusetts Eye and Ear Infirmary) — Principal investigator
First posted
Jun 11, 2020
Start date
Nov 6, 2020
Primary completion
Jun 30, 2026
Completion
Sep 30, 2026
Last update
Oct 6, 2026

Study contacts

Eliezer Peli, MSc, OD
study director · Schepens Eye Research Institute of Massachusetts Eye and Ear

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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