An observational study in Endocarditis and Neurologic Complication, sponsored by Gros, Alexandre, M.D.. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-05-19.
Sponsored by Gros, Alexandre, M.D. · Observational
Surgical delay in severe endocardits, with neurological complications, is still debated. Early surgery, if indicated, permits to avoid new embolic events, or to fix valvular damages, but can create or increase a cerebral hemorrage.
Hypothesis Cardiac surgery, as soon as possible, if indicated, would reduce mortality, in severe left endocarditis, with neurological complications.
Primary objective To assess the impact of early versus late cardiac surgery on mortality at 1 year, in patients with severe endocarditis, with neurological complications.
Primary endpoint:
Secondary endpoints:
Surgical delay in severe endocardits, with neurological complications, is still debated. Early surgery, if indicated, permits to avoid new embolic events, or to fix valvular damages, but can create or increase a cerebral hemorrage.
Hypothesis Cardiac surgery, as soon as possible, if indicated, would reduce mortality, in severe left endocarditis, with neurological complications.
Primary objective To assess the impact of early versus late cardiac surgery on mortality at 1 year, in patients with severe endocarditis, with neurological complications.
Primary endpoint:
Secondary endpoints:
Methods Multicentric study (7 French university hospitals). Retrospective study: from august 2010 to december 2017. Propensity score matching study. 192 patients are included.
170 studies on the registry are indexed under Endocarditis; 51 are open to participants now.
This study's enrollment of 192 is below the median of 263 across 81 observational studies indexed under Endocarditis.
Browse Endocarditis studies →This is the only study on the registry with Gros, Alexandre, M.D. as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Hospitalized patients in intensive care unit. They all have an indication of surgery, but they are not all operated (neurological or others contre-indications).
Exclusion Criteria:
Cardiac surgery, if indicated, delayed or not by neurological complications
Mortality
Death from any cause
Time frame: at 1 year after the diagnosis of endocarditis
Neurogical tolerance
Modified Rankin score after cardiac surgery, 0 (no symptoms at all) to 6 (death)
Time frame: At 6 months
No study locations are listed for this record.
Plan to share: Undecided — All individual data are available in an Excel file.
No publications or documents are linked to this record.
This study is completed, as verified in May 2020. You cannot join it, but the record below documents what was studied.
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