A Phase 1 interventional study of RhEGF and Plain Collagen in Periodontitis, sponsored by SVS Institute of Dental Sciences. Status unknown at 1 site in India. Open to participants aged 20 Years to 55 Years. Per ClinicalTrials.gov, last updated 2020-05-05.
Sponsored by SVS Institute of Dental Sciences · Phase 1, Interventional, and Treatment
A sulcular incision will be made through each recession area and the tissues will be gradually undermined including the base of the interdental papilla. At the recession sites rhEGF incorporated absorbable collagen membrane will be gradually manipulated into the pouch through the tunnel till it covers the recession sites and will be stabilized with sutures.
IN TEST SITE :
Local anesthesia will be administered and Vertical incisions will be given at interdental papillae away from recession defect site and a pouch will be created. A sulcular incision will be made through each recession area and the tissues will be gradually undermined including the base of the interdental papilla. At the recession sites rhEGF incorporated absorbable collagen membrane will be gradually manipulated into the pouch through the tunnel till it covers the recession sites and will be stabilized with sutures.
IN CONTROL SITE:
Same procedure will be done as the test site but plain collagen membrane will be gradually manipulated into the pouch through the tunnel till it covers the recession sites and will be stabilized with sutures.
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's planned enrollment of 30 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →SVS Institute of Dental Sciences is the lead sponsor of 21 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
EGF impregnated in collagen membrane is placed in gingival recession defects
Drug: RhEGF
plain collagen membrane is placed in gingival recession defects
Drug: Plain Collagen
The EGF impregnated membrane will be placed upon the recession site and will be stabilized by suturing it to the lingual papillae using 4-0 absorbable sutures. The flap will be coronally advanced as far as possible to cover the membrane and will be sutured to the buccal interdental papillae with 4-0 absorbable sutures (Trulenetm, Healthium Medtech Pvt Ltd, Bangalore, India). Standard recall and maintenance regimen will be followed and subjects will be encouraged to report to the department on a monthly basis.
Also known as: EGF+Collagen
A collagen membrane without FGF-2 will be used.
Also known as: Control group
Recession depth (RD)
Recession depth (RD) - measured from cementoenamel junction to most apical extension of gingival margin.
Time frame: Base line to 6months.
Width of keratinized gingiva (KGW)
Width of keratinized gingiva (KGW) - distance between gingival margin and mucogingival junction will be evaluated.
Time frame: Base line to 6months.
This study is status unknown, as verified in May 2020. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
SVS Institute of Dental Sciences