An interventional study of Left colon resection and Sigmoid colon resection in Colon Cancer, sponsored by Russian Society of Colorectal Surgeons. Recruiting at 1 site in Russia. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-08-17.
Sponsored by Russian Society of Colorectal Surgeons · Not applicable, Interventional, and Treatment
Among 11 studies in Colonic Neoplasms with a site in Russia — 4 open to participants now, 7 under way, 3 of them phase 3. Colonic Neoplasms · Russia.
Among the 11 studies in Colonic Neoplasms with a site in Russia, this one is one of 2 that started in 2020, is one of 2 with no phase, and was the 3rd registered.
2,457 studies on the registry are indexed under Colonic Neoplasms; 458 are open to participants now.
This study's planned enrollment of 1,381 is above the median of 75 across 1,711 interventional studies indexed under Colonic Neoplasms.
Browse Colonic Neoplasms studies →4 of the 11 studies in Colonic Neoplasms with a site in Russia are open now, in 11 countries. Each count lists the studies.
Of the 326 Colonic Neoplasms studies recruiting now, 203 (62%) set no upper age limit and 71 (22%) stop at 75 or younger; 19 take children under 18; 34 take healthy volunteers.
This study: 18 Years to 75 Years · all sexes · no healthy volunteers.
The full table on the hub →11 studies; the count open now beside each. This study's row is marked.
First in 2013; this study’s year is marked. 2 started in 2020.
Median enrollment 669 across the 6 interventional studies, 700 across the 5 observational. Of the 4 that completed or were terminated, 0 (0%) have results posted.
3 of 11 have an industry lead sponsor. The 9 most frequent:
Russian Society of Colorectal Surgeons is the lead sponsor of 15 studies on the registry; 2 are open to participants now.
Russian Society of Colorectal Surgeons has 2 studies filed under Colonic Neoplasms — fewer than ten, so there is no comparison to draw.
3 of the studies in Colonic Neoplasms with a site in Russia that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06119867Phase 3Russian Society of Colorectal SurgeonsCompariSon Between the EuroPeAn and Japanese pathologiCal InvEstigation for Colon Cancer (SPACE) | 2027-04-12 |
| NCT06043947N.N. Petrov National Medical Research Center of OncologySurvival Monitoring in Russian Cancer Registries | 2026-12-31 |
| NCT07448662Blokhin's Russian Cancer Research CenterLocal Treatment Strategies for Brain Metastases of Colorectal Cancer | 2027-10-01 |
Among the 11 studies in Colonic Neoplasms with a site in Russia, from their registry updates:
Nothing recorded among them since 2026-09-25.
The efficiency of the D3 lymph node dissection is still controversial for left colon cancer patients. This study will try find difference in 5-year overall survival between D2 and D3 lymph node dissection. Investigation of the functional and short-term outcomes will clarify safety of the D3 lymph node dissection.
Discussion about optimal type of lymph node dissection in colorectal cancer continues during last 15 years, when in Europe was presented concept of complete mesocolic excision. However, this concepts is very close to Japanese D3 lymph node dissection and in the first view it seems the same but principal differences were found. Japanese concept is partial resection of the bowel according feeding artery (short bowel specimen, long lymphovascular pedicle), opposite European concept is wide resection of the bowel like hemicolectomy or extended hemicolectomy, sigmoidectomy. In complete mesocolic excision anatomical landmarks are still unclear but in Japanese guidelines it has anatomical margins which can standardize this procedure. Also nerve sparing technique around root of inferior mesenteric artery was described. One more difference is in histological examination of the specimen. European concept is to pay more attention to the quality of complete mesocolic excision and less - to the number of investigated lymph nodes. In Japan lymph node extraction is performed by surgical team from the fresh specimen and send to pathologist separately (each group of lymph nodes). Considering the absence of randomized control trials for patients with left colon cancer DILEMMA trial was started using Japanese approach
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
For tumours in splenic flexure and proximal and mid part of descending colon lymph nodes 232 and 231 will be removed. For tumours in distal part of descending colon and proximal sigmoid lymph nodes 231, 232 and partially 241, 242 (considering variation of the feeding artery) will be removed. For tumours in the mid part of sigmoid colon lymph nodes 241, 242 will be removed. For tumours in the rectosigmoid junction 251, 252 groups of the lymph node will be removed.
Procedure: Left colon resection · Procedure: Sigmoid colon resection · Procedure: Distal sigmoid colon resection or anterior resection
For tumours in splenic flexure and proximal and mid part of descending colon lymph nodes 232, 231 and 253 will be removed. For tumours in distal part of descending colon and proximal sigmoid lymph nodes 231, 232 and 253 and partially 241, 242 (considering variation of the feeding artery) will be removed. For tumours in the mid part of sigmoid colon lymph nodes 241, 242 and 253 will be removed. For tumours in the rectosigmoid junction 251, 252 and 253 groups of the lymph node will be removed.
Procedure: Left colon resection · Procedure: Sigmoid colon resection · Procedure: Distal sigmoid colon resection or anterior resection
This procedure is performed for tumours in splenic flexure and proximal and descending colon. Left colic artery is divided at its origin. Sigmoid arteries and superior rectal arteries are preserved. Inferior mesenteric vein is divided at the lower border of the pancreas. The colon is divided about 10 cm proximal and distal to the tumour. Mesocolic fascia is preserved and the length of the "vessel trunk" of the mesocolon corresponds to the level of lymph node dissection. After removal of the resected colonic segment a handsewn or stapler end-to-end or side-to-side colonic anastomosis is performed.
This procedure is performed for tumours in sigmoid colon. Corresponding sigmoid arteries are divided at their origin. Left colic artery and superior rectal artery are preserved. Inferior mesenteric vein is divide close to the left colic artery. Proximal and distal margin compose 10 cm from the tumour. Mesocolic fascia is preserved and the length of the "vessel trunk" of the mesocolon corresponds to the level of lymph nodes dissection. After removal of the resected colonic segment a handsewn end-to-end or side-to-side or stapler colonic anastomosis is performed.
This procedure is performed for tumours in distal sigmoid colon or rectosigmoid junction. Superior rectal artery is divided below the origin of left colic artery. Left colic artery is preserved. Inferior mesenteric vein is divide close to the left colic artery. The colon is divided about 10 cm proximal and 5 cm distal to the tumour. Mesocolic fascia is preserved and the length of the "vessel trunk" of the mesocolon corresponds to the level of lymph node dissection. After removal of the resected colonic segment handsewn or stapler colo-rectal anastomosis is performed.
5-year overall survival
Probability to be alive measured in %, where 100% means that patients have a 100% probability to be alive and 0% means that patients have 0% probability to be alive
Time frame: Up to 5 years post-operatively
5-year disease free survival
Probability to be alive with no signs of local or distant recurrence measured in %, where 100% means that patients have a 100% probability to be alive with no signs of local or distant recurrence and 0% means that patients have 0% probability to be alive with no signs of local or distant recurrence
Time frame: Up to 5 years post-operatively
Postoperative sexual dysfunction
The rate of ejaculation problems in sexually active men and the rate of decreased vaginal lubricant production in sexually active women, measured in % from the total number of male/female patients
Time frame: Up to 1 year post-operatively
Apical lymph node involvement rate
The rate of lymph nodes 253 with metastatic cells among all lymph nodes 253, measured in %
Time frame: 1 month after surgery
Intraoperative complications rate
The rate of any complications within the course of surgery
Time frame: Day 0
Early postoperative complications rate
The rate of surgical and infectious complications
Time frame: 1-30 days after surgery
Mortality
The rate of death from all causes
Time frame: 0-30 days after surgery
Late postoperative complications rate
The rate of surgical and infectious complications
Time frame: 30-180 days after surgery
Plan to share: No
No publications or documents are linked to this record.
Started Mar 2020 (actual). Primary completion is estimated for Dec 2028, 105 months after the start.
Of 382 non-industry interventional studies with no phase under Colonic Neoplasms, half reached primary completion within 31 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 55. This study's planned 105 months is above that.
Counting every sponsor, half of 404 studies reached it within 30 months; a quarter within 16 and three quarters within 51.
How these figures are worked out, and which studies are left out of them.
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Russian Society of Colorectal Surgeons