An interventional study of gingival crevicular fluid evaluation in Periodontitis, sponsored by University of Messina. Completed at 1 site in Italy. Open to participants aged 32 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-04-20.
Sponsored by University of Messina · Not applicable, Interventional, and Supportive care
In light of the controversy that are already approved but that however still exists regarding the efficacy and influence of the decontaminant tools for the management of Periodontitis (, the aim of this study was to evaluate, at 6 months follow-up, the post-treatment clinical parameters and immunological and gingival microbial profiles in patients with periodontitis, treated by either SRP in addition to phytotherapeutic drug or SRP alone.
This trial was conducted in accordance with the World Medical Association's Declaration of Helsinki of 1975, and reviewed in 2008. The local ethical committee of the University of Messina approved the study protocol and each patient was carefully informed about the possible inherent risks of the study and provided their informed written consent 34 patients, 18 men and 16 women, aged 27 to 65 (mean age 44.2) were assessed for eligibility . In all subjects, subgingival plaque was acquired from 4 separate proximal sites at 365 days after therapy.
The Gingival Crevicular Fluid (GCF) was gathered, at the same time from other four different non-contiguous interproximal sites using filter paper strips‡ as previously described. The levels of IL-1β, IL-10 and TNF-α were recognized by conventional enzyme-linked immunosorbent assay using an equation with software using a five polynomial parameter. Each selected subject underwent randomly, without anaesthesia, at the same time and after recording periodontal parameters, the two following treatments: in one, were treated as conventional Scaling and Root Planing (SRP) + phytotherapeutic drug (Neuridase), while the other group were treated as conventional SRP alone
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's enrollment of 34 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →University of Messina is the lead sponsor of 53 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
scaling and root planing alone
Diagnostic Test: gingival crevicular fluid evaluation
scaling and root planing plus phytotherapeutic agent
Diagnostic Test: gingival crevicular fluid evaluation
anaysis of interleukins in gingival crevicular fluid
Clinical Attachment level
Analysis of reduction of clinical attachment level
Time frame: 180 days
Plan to share: Yes — Sharing inflammatory results
Supporting information: Study protocol, Sap
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This study is completed, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
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University of Messina