An interventional study of 1 mA tDCS and 1.5 mA tDCS in Healthy, sponsored by University of Messina. Terminated at 1 site in Italy. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-12-16.
Sponsored by University of Messina · Not applicable, Interventional, and Basic science
This is a randomized double-blind sham controlled systematic investigation to understand the importance of the brain region that controls the tongue and the submental muscle region on perceived appetite. The results of this study can have clinical implications for a phenomenon called hyperphagia.
After explaning all the procedure and the scientific aims of the project to participants and completing the informed consent form, each participant will be randomly asked to take part in the experiment while fasting for at least 6 hours or completely sated, to enable an investigation of the role of the basic level of hunger on the effects of brain stimulation on subjective appetite. Different intensities of stimulation (1 mA, 1.5 mA, and sham) will be used in three separate groups, to which participants will be randomly assigned, in a double-blind manner.
University of Messina is the lead sponsor of 53 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants receive the stimulation with an intensity of 1 mA.
Device: 1 mA tDCS
Participants receive the stimulation with an intensity of 1.5 mA.
Device: 1.5 mA tDCS
Participants receive the sham stimulation (zero electric current after a short initial increase).
Device: Sham tDCS
One session with stimulation intensity of 1 mA.
One session with stimulation intensity of 1.5 mA.
One session of sham stimulation.
Change in the subjective rating of appetite
A visual analogue scale (VAS; from 0 meaning not hungry at all, to 100 meaning extremely hungry), will be used to record the perceived level of hunger before and after the stimulation to enable evaluation of the effects of stimulation on perceived appetite.
Time frame: Baseline measurement in the begninning of the experiment before stimulation versus post stimulation, exactly after the stimulation protocol has finished (with an approximate time interval of 1 hour)
Change in excitability of the submental muscle region in primary motor cortex
Recording motor evoked potentials from the area of the submental region of the motor cortex in addition to a control site (APB muscle), to allow for comparisons of the amplitude of MEPs before and after stimulation to draw conclusions about the effect of stimulation and its contribution to the potential behavioral modulations of tDCS
Time frame: Baseline measurement in the begninning of the experiment before stimulation versus post stimulation, exactly after the stimulation protocol has finished (with an approximate time interval of 1 hour)
Plan to share: No
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This study is terminated, as verified in Aug 2021. You cannot join it, but the record below documents what was studied.
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University of Messina