An observational study in Amblyopia and Strabismus, sponsored by The Cleveland Clinic. Recruiting at 1 site in United States. Open to participants aged 6 Months to 90 Years. Per ClinicalTrials.gov, last updated 2026-03-04.
Sponsored by The Cleveland Clinic · Observational
Amblyopia and strabismus are characterized by a reduction in visual acuity, contrast sensitivity, grating acuity, vernier acuity, reading difficulties and binocular visual function deficits. Treated patients have residual visual function deficits. The purpose of the current study is to quantify various visual functions in amblyopic and strabismic participants at baseline, during and at the completion of treatment.
To examine the response of therapy on visual functions in amblyopic and strabismic participants.
The following visual functions will be measured prior to treatment. Eye movements, contrast sensitivity, grating acuity, visual acuity, vernier acuity, binocular visual functions, reading and visual scanning will be measured. The testing will comprise of one or more of the above paradigms depending on participant's cooperation and understanding as majority of the study participants will be children. The above measurements will be repeated during amblyopia therapy ( which comprises of glasses, patching and/or atropine eye drops) and at the completion of treatment. For participants with strabismus requiring strabismus surgery the measurements will be repeated after strabismus surgery.
189 studies on the registry are indexed under Amblyopia; 41 are open to participants now.
This study's planned enrollment of 150 is close to the median of 156 across 39 observational studies indexed under Amblyopia.
Browse Amblyopia studies →The Cleveland Clinic is the lead sponsor of 831 studies on the registry; 119 are open to participants now.
Of its 90 completed or terminated interventional studies of FDA-regulated products, 73 (81%) have results posted.
Counted across the registry records on this site, refreshed daily.
children with diagnosis of strabismus and/or amblyopia
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Subjects who state they have no eye or neurologic problems or disease other than perhaps wearing glasses or contact lenses and upon review of medical history.
Clinical diagnosis of amblyopia
Behavioral: Patching therapy, Glasses
Patching, glasses and strabismus surgery are commonly employed measures in treatment of amblyopia and strabismus.
Also known as: Strabismus surgery
Visual Functions
contrast sensitivity
Time frame: 0-3 years depending on duration of treatment
Visual Functions
visual acuity
Time frame: 0-3 years depending on duration of treatment
Visual functions
vernier acuity
Time frame: 0-3 years depending on duration of treatment
Visual functions
grating acuity
Time frame: 0-3 years depending on duration of treatment
Visual functions
binocular functions- stereopsis, inter-ocular functions
Time frame: 0-3 years depending on duration of treatment
Visual functions
eye movement measurements
Time frame: 0-3 years depending on duration of treatment
Visual functions
reading- reading speeds, eye movement measurements
Time frame: 0-3 years depending on duration of treatment
Plan to share: Yes — Research publications require inclusion of de-identified data in the manuscript. We will also be presenting the data at local, national and international conferences.
Supporting information: Statistical analysis plan, Analytic code
Time frame: starting 6 months after publication
Access criteria: The de-identified research data will be shared with colleagues and will be published after peer-review.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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