An interventional study of Internal jugular vein catheterization and Subclavian vein catheterization in Critical Illness, sponsored by Hospital Civil de Guadalajara. Recruiting at 1 site in Mexico. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-03-12.
Sponsored by Hospital Civil de Guadalajara · Not applicable, Interventional, and Treatment
Most recent guidelines suggest central venous access must be performed with real-time ultrasound guidance, and the most recommended site for cannulation is internal jugular vein (IJV); however, it is recognized that evidence for other sites is, at present, limited. Besides, guidelines does not account for patients with small vein cross-sectional area and/or respirophasic collapse, which can make the procedure more difficult or even impossible. The investigators aim to compare three different insertion sites for central venous access, with real-time ultrasound guidance
Ultrasound-guided cannulation of central veins is successful in >95% of the cases, according to the largest study so far. However, this and other studies with similar success rate, are performed in patients with general anesthesia and/or neuromuscular blockade, without spontaneous respiratory efforts. Critical care physicians and many other specialists frequently need to cannulate patients in special circumstances as hypovolemia, pain, anxiety, and respiratory efforts that promotes respirophasic variation in cross-sectional area, and even complete collapse of the vessel. These changes can increase the probability of posterior wall or arterial puncture, hematomas, pneumothorax, etc. Supraclavicular approach for cannulation of the subclavian vein is a method described since 1965, also giving direct access to the innominate vein, a larger vessel which is rarely collapsible regardless of volume status or respiratory efforts. Based on a previous pilot trial, in this multi-center, prospective, randomized, controlled trial, the investigators aim to compare the successfulness and safety of ultrasound-guided central venous cannulation at 3 different sites: internal jugular, subclavian, and innominate veins.
1,780 studies on the registry are indexed under Critical Illness; 442 are open to participants now.
This study's planned enrollment of 315 is above the median of 90 across 926 interventional studies indexed under Critical Illness.
Browse Critical Illness studies →Hospital Civil de Guadalajara is the lead sponsor of 41 studies on the registry; 11 are open to participants now.
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Exclusion Criteria:
Less than 18 years-old
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Ultrasound-guided central venous catheterization at internal jugular vein site
Procedure: Internal jugular vein catheterization
Ultrasound-guided central venous catheterization at subclavian vein site
Procedure: Subclavian vein catheterization
Ultrasound-guided central venous catheterization at innominate vein site
Procedure: Innominate vein catheterization
Catheterization of internal jugular vein with real-time (in-plane) method, with neutral neck position. Standard aseptic technique.
Catheterization of subclavian/axillary vein with infra-clavicular approach with real-time (in-plane) method, without shoulder retraction. Standard aseptic technique.
Catheterization of innominate vein with supra-clavicular approach with real-time (in-plane) method, with neutral shoulder position and no shoulder retraction. Standard aseptic technique.
Cannulation failure rate
Failure to cannulate selected vein at first attempt
Time frame: Baseline
Central line-associated blood infection rate
Confirmed with blood cultures
Time frame: 28 days
Collapsibility associated with failure
Percentage of vein collapsibility independently associated with cannulation failure
Time frame: Baseline
Cannulation number of attempts
Number of attempts needed to attain cannulation
Time frame: Baseline
Procedure time
Time from skin puncture to guidewire confirmed into vessel (minutes)
Time frame: Baseline
Arterial puncture rate
Confirmed immediately after procedure with vascular ultrasound
Time frame: Baseline
Hematoma formation rate
Confirmed immediately after procedure with vascular ultrasound
Time frame: 7 days
Neumothorax rate
Confirmed immediately after procedure with lung ultrasound
Time frame: 7 days
Hemothorax rate
Confirmed immediately after procedure with lung ultrasound
Time frame: 7 days
Plan to share: No
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Hospital Civil de Guadalajara