An interventional study of disconnect pulmonary vague nerve branches in Postoperative Chronic Cough, sponsored by Han Yuan. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-06-22.
Sponsored by Han Yuan · Not applicable, Interventional, and Prevention
The purpose of this study was to determine whether disconnecting pulmonary vagus nerve branch can abatement chronic cough in patients undergoing unilateral thoracoscopic lobectomy,compared with preserving pulmonary vagus nerve branch.
After screening for the Inclusion criteria and the exclusion criteria, 116 patients undergoing unilateral thoracoscopic lobectomy are randomly assigned to two groups, disconnecting pulmonary vague nerve branches and preserving pulmonary vague nerve branches. The incidence of chronic cough after surgery is compared between groups.
346 studies on the registry are indexed under Cough; 71 are open to participants now.
This study's enrollment of 116 is above the median of 70 across 263 interventional studies indexed under Cough.
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Exclusion Criteria:
disconnect pulmonary vague nerve branches
Procedure: disconnect pulmonary vague nerve branches
preserve the pulmonary vague nerve branches
When the operation is in the right side, the Azygous vein bow is used as the marker, and in the left side, the aortic arch is used as the marker to identify the vagus nerve trunk.Then the surgeons dissect the vagus nerve trunk. This is used as a clue to find the vagus nerve pulmonary branch leading to the hilum. The position of the detachment is after the anterior and posterior pulmonary branches of the vagus nerve separating from the trunk and before the formation of the lung plexus.
The incidence of chronic cough after surgery
More than 8 weeks after surgery, there is no clear cause of cough with stable chest CT excluding the diagnosis of postnasal drip syndrome, asthma or the use of Angiotensin-converting enzyme inhibitor(ACEI), etc.
Time frame: 3 months after surgery
The incidence of chronic cough after surgery
More than 8 weeks after surgery, there is no clear cause of cough with stable chest CT excluding the diagnosis of postnasal drip syndrome, asthma or the use of Angiotensin-converting enzyme inhibitor(ACEI), etc.
Time frame: 1 month after surgery
The score of the LCQ-MC scale after surgery
The LCQ-MC was designed for the assessment of a chronic cough, consists of 19 items and three domains.
Time frame: 1 month and 3 months after surgery
Length of operation
Time frame: during the operation
volume of bleeding
Time frame: during the operation
volume of postoperative drainage
Time frame: within 30 days after surgery
the frequence of perioperative arrhythmia
Time frame: during the operation
the incidence of Postoperative complication
pulmonary complications, intestinal obstruction, pulmonary embolism, acute respiratory failure, acute renal failure, wound infection, cerebrovascular accident
Time frame: within 30 days after surgery
the score of Cough symptom
The score was used to record daily symptom score for cough severity.The scale is scored by 4 levels at day and night respectively.The higher score means worse symptom.
Time frame: postoperative 1 day,2 days,3 days,4 days,5 days,6 days
the time of extubation
Time frame: within 30 days after surgery
the incidence of gastrointestinal symptoms
gastrointestinal symptoms include anorexia, belching, reflux, diarrhea, nausea
Time frame: within 3 months after surgery
the incidence of postoperative hospitalization
Time frame: within 30 days after surgery
pulmonary function 30 months after surgery
maximal voluntary ventilation, diffusing capacity of the lungs for carbon monoxideand forced expiratory volume
Time frame: 30 months after surgery
This study is completed, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.
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