CClinicalTrials.gg
CompletedNCT02992600Updated Jul 25, 2022

Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes

An observational study in Postoperative Cognitive Dysfunction, sponsored by Han Yuan. Completed at 1 site in China. Open to participants aged 60 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-07-25.

Sponsored by Han Yuan · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
300
Ages
60 Years to 85 Years
Sex
All
01

Study summary

To study on the Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes.To explore whether the olfactory dysfunction could be used as a predictor of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.

02

Conditions studied

  • Postoperative Cognitive Dysfunction

Keywords

  • non-cardiac surgery
  • Postoperative Cognitive Dysfunction
03

In context

Postoperative Cognitive Complications

264 studies on the registry are indexed under Postoperative Cognitive Complications; 54 are open to participants now.

This study's enrollment of 300 is above the median of 100 across 113 observational studies indexed under Postoperative Cognitive Complications.

Browse Postoperative Cognitive Complications studies →

Lead sponsor

Han Yuan is the lead sponsor of 5 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
60 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

We included 300 male and female patients undergoing non-cardiac surgery at the Affiliated Hospital of Xuzhou Medical University and 30 healthy volunteers.

Inclusion criteria

  • Between 60 to 85 years old;
  • Undergoing non-cardiac and non-neurological surgery under general anesthesia;
  • Expected hospital stay ≥5 days;
  • American Society of Anesthesiologists class I or II.

Exclusion criteria

Exclusion criteria:

  • Mental or neurodegenerative diseases;
  • History of severe trauma or surgery within one year;
  • History of nasal or sinus illness or surgery;
  • Cold or influenza within 3 weeks;
  • Significant history of organ dysfunction;
  • Previous neuropsychological testing;
  • Difficulty to perform tests (including severe visual or auditory disorders);
  • Mini-Mental State Examination (MMSE) \<24 points, \<20 points if the participant only attended elementary school, or \<17 points if the participant did not go to school.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
300 participants (actual)
Target follow-up
7 Days
Patient registry
Yes
Biospecimen retention
Samples with dna

Groups and cohorts

  • study group

    300 male and female patients undergoing non-cardiac surgery are enrolled at the Affiliated Hospital of Xuzhou Medical University \[Jiangsu China\]. Patients will be divided into POCD and non-POCD groups according to the scores of neuropsychological tests.

  • control group

    30 healthy volunteers are enrolled for calculating the Z-scores of study group.

06

What researchers measure

Primary outcomes

  1. the neuropsychological test battery to measure cognitive function

    Time frame: 1 day before surgery(baseline)

  2. olfaction test to measure the sense of smell

    Time frame: 1 day before surgery(baseline)

  3. the neuropsychological tests to measure cognitive function

    Time frame: within 5 to 10 days (average of 7 days) after surgery

  4. olfaction test to measure the sense of smell

    Time frame: within 5 to 10 days (average of 7 days) after surgery

07

Study locations

1 site
  • Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University
    Xuzhou, Jiangsu, China
08

References and documents

Individual participant data

Plan to share: Yes — within six months after the trial complete

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 25, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02992600
Lead sponsor
Han Yuan
Responsible party
Han Yuan (Physician in Anesthesiology, Xuzhou Medical University) — Sponsor-investigator
First posted
Dec 14, 2016
Start date
Dec 2016
Primary completion
Jul 2017
Completion
Jul 2017
Last update
Jul 25, 2022
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion