ClinicalTrials.gg
CompletedNCT04238260Updated Jun 12, 2026

Enhancing Physical Therapy Best Practice for Improving Walking After Stroke

An interventional study of Enhancing Physical Therapy Usual Care and Physical Therapy Usual Care in Stroke, Cerebral Infarction and Brain Ischemia, sponsored by University of British Columbia. Completed at 1 site in Canada. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2026-06-12.

Primary conditionCerebral InfarctionRegistry: StrokeReclassifiedWhy we changed it
Registry
Stroke — the first condition term the registry derived for this study.
ClinicalTrials.gg
Cerebral Infarction
Why
  1. The study's listed conditions name Cerebral Infarction, a narrower term within Stroke.
Confidence
High: the new condition is named in the study's own listed conditions. Of 351 hand-checked studies reclassified this way, 68% were exactly right and 84% in the right disease family; the registry's first term was right for 5% (measured 2026-10-21). How we classify →
Wrong?
Tell us the study's main condition →

Sponsored by University of British Columbia · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
306
Allocation
Randomized
Ages
19 Years and older
Sex
All
01

Study summary

The aim of this study is to assess the effect of implementing best practices into current stroke rehabilitation physical therapy on walking outcomes. Participants will also be provided an activity monitor to help them track and target their walking practice to determine if this can improve walking ability.

Read the detailed description

This multi-site study will have each site start in usual care with participants consented to collecting outcome measures. The twelve inpatient stroke units include: Kelowna General Hospital, Nanaimo Regional General Hospital, Glenrose Rehabilitation Hospital, Saskatoon City Hospital, Wascana Rehabilitation Centre, Joseph Brant Hospital, Bruyère Hospital, Freeport Grand River Hospital, CIUSSS-de-l'Estrie-CHUS Centre de réadaptation de l'Estrie, Centre interdisciplinaire de recherche en réadaptation et intégration sociale, Dr. Everett Chalmers Regional Hospital, and Queen Elizabeth Hospital. Each site will randomly switch over to Enhanced Usual Care (best practice implementation) where all physical therapists at the site will be educated on delivery of best practice for locomotor retraining. The specific therapy activities are at the discretion of the physical therapist; however, physical therapists must work towards thirty minutes of weight-bearing/stepping activity at greater than forty percent heart rate reserve. Participants will continue to be consented to collecting outcome measures. Additionally, participants will be given and trained to use activity watches to monitor their own progress.

02

Conditions studied

  • Stroke
  • Cerebral Infarction
  • Brain Ischemia
  • Infarction, Brain

Keywords

  • Stroke
  • Lower extremity
  • Rehabilitation
  • Wearable device
  • Exercise
  • Clinical Trial
03

In context

Cerebral Infarction Reclassified

219 studies on the registry are indexed under Cerebral Infarction; 46 are open to participants now.

This study's enrollment of 306 is above the median of 120 across 139 interventional studies indexed under Cerebral Infarction.

Browse Cerebral Infarction studies →

Lead sponsor

University of British Columbia is the lead sponsor of 1,339 studies on the registry; 259 are open to participants now.

Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.

Compared within Cerebral Infarction, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Stroke. The counts are of registry records indexed under each term, refreshed daily. How we classify →

04

Who can participate

Ages eligible
19 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Admitted by inpatient or day stroke rehabilitation
  • Improved walking is a rehabilitation goal
  • Within 12 weeks post hemorrhagic or ischemic CVA with hemiparesis (confirmed by medical chart or motor assessment)
  • Able to ambulate at least 5 steps. May use assistive and/or orthotic device and maximum one person assist
  • Overground walking speed slower than normal
  • Able to understand and follow directions
  • Greater than or equal to 19 years of age
  • Medically stable

Exclusion criteria

Exclusion Criteria:

  • Pre-stroke health included a serious gait disorder or disease that affected ambulation (musculoskeletal conditions, amputation, surgery/arthroplasty in the last 6 months, etc.)
  • Pre-stroke health included a neurological condition (such as Parkinson's disease or Multiple Sclerosis) or other serious medical condition (active cancer, uncontrolled diabetes)
  • Excessive pain in the body/joint preventing participation in an exercise intervention
  • Participating in an experimental drug field study
  • Participating in another formal exercise rehabilitation clinical trial
  • Expected to receive \<2 weeks daily in-/out- patient rehabilitation
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Sequential assignment
Masking
Single (Outcomes assessor)
Enrollment
306 participants (actual)

Study arms

  • Active comparator
    Usual Physical Therapy Care

    Physical Therapists continue usual care

    Behavioral: Physical Therapy Usual Care

  • Experimental
    Enhanced Physical Therapy Usual Care

    Best practice implemented

    Behavioral: Enhancing Physical Therapy Usual Care

Interventions

  • BehavioralEnhancing Physical Therapy Usual Care

    The protocol is focused on the completion of a minimum of 30 minutes of weight-bearing, walking-related activities that progressively increase in intensity informed by heart rate and step counters over 4 weeks.

  • BehavioralPhysical Therapy Usual Care

    Usual physical therapy

06

What researchers measure

Primary outcomes

  1. Six-minute walk Test

    This test measures distance a participant can walk in 6 minutes.

    Time frame: 4 weeks

Secondary outcomes

  1. Six-minute walk test

    This test measures distance a participant can walk in 6 minutes.

    Time frame: 12 months post-stroke

  2. Blood pressure

    Blood pressure measures physiological effects of the intervention

    Time frame: 4 weeks & 12 months post-stroke

  3. Euro-QOL 5D-5L

    This test is the most widely used instrument to measure quality of life.

    Time frame: 4 weeks & 12 months post-stroke

  4. Montreal Cognitive Assessment

    This test measures levels of cognitive function. Min 0, max 30, with higher scores reflecting better cognition.

    Time frame: 4 weeks & 12 months post-stroke

  5. Short Performance Physical Battery

    This test measures lower extremity function. Min value 0, max value 12. Higher scores reflect better lower extremity function

    Time frame: 4 weeks & 12 months post-stroke

  6. Patient Health Questionnaire-9 (PHQ-9)

    This test screens for depression. Min 0, max 27. Higher values reflect more severe symptoms.

    Time frame: 4 weeks & 12 months post-stroke

  7. Modified Rankin Scale (mRS)

    This scale measures the degree of disability. Score range: minimum 0 to maximum 6. Lower score means a better outcome.

    Time frame: 4 weeks & 12 months post-stroke

  8. Physical Activity Scale for the Elderly (PASE)

    This test assesses physical activity, including leisure, household, and occupational activity. Score range: minimum 0 to maximum 400 or more. Higher score means a better outcome

    Time frame: 12 months post-stroke

  9. Step activity monitor

    The number of steps per day over 3 days

    Time frame: 12 months post stroke

  10. Gait speed

    self-paced gait speed in metre/second

    Time frame: 4 week and 12 month post-stroke

07

Study locations

1 site
  • University of British Columbia
    Vancouver, British Columbia V5Z2G9, Canada
08

References and documents

Publications

  • Tang WK, Lu H, Leung TWH, Fong KNK, Chan SKY, Liew VWJ. A double-blind randomized control trial of transcranial direct current stimulation in post-stroke fatigue. Front Neurol. 2026 May 7;17:1658764. doi: 10.3389/fneur.2026.1658764. eCollection 2026. PubMed 42180207 ↗
  • Ackerley S, Hung SH, Sheehy L, Donkers SJ, Timofeeva P, Best KL, Peters S, Park SS, Ouellet B, Ezeugwu VE, Milot MH, Sakakibara BM, Eng JJ, Connell LA. Exploring factors influencing implementation across the explanatory-to-pragmatic trial continuum: a sequential qualitative integration of delivering higher-intensity walking exercise within inpatient stroke rehabilitation. Implement Sci Commun. 2026 Jan 8;7(1):44. doi: 10.1186/s43058-025-00812-y. PubMed 41508158 ↗
  • Hung SH, Ackerley S, Connell LA, Bayley MT, Best KL, Donkers SJ, Dukelow SP, Ezeugwu VE, Milot MH, Peters S, Sakakibara BM, Sheehy L, Yao J, Eng JJ. Real-World Experiences of Therapy Staff Implementing an Intensive Rehabilitation Protocol in Canadian Stroke Inpatient Rehabilitation Settings: A Multi-Site Survey Study. Phys Ther. 2025 Oct 1;105(10):pzaf111. doi: 10.1093/ptj/pzaf111. PubMed 41139309 ↗
  • Yan Y, Eng JJ, Hung SH, Bayley MT, Best KL, Connell LA, Donkers SJ, Dukelow SP, Ezeugwu VE, Milot MH, Sakakibara BM, Sheehy L, Wong H, Yao J, Peters S. Aerobic minutes and step number remain low in inpatient stroke rehabilitation. PLoS One. 2025 Jul 28;20(7):e0328930. doi: 10.1371/journal.pone.0328930. eCollection 2025. PubMed 40720450 ↗
  • Peters S, Hung SH, Bayley MT, Best KL, Connell LA, Donkers SJ, Dukelow SP, Ezeugwu VE, Milot MH, Sakakibara BM, Sheehy L, Wong H, Yang Y, Yao J, Eng JJ. Safety and effectiveness of the Walk 'n Watch structured, progressive exercise protocol delivered by physical therapists for inpatient stroke rehabilitation in Canada: a phase 3, multisite, pragmatic, stepped-wedge, cluster-randomised controlled trial. Lancet Neurol. 2025 Aug;24(8):643-655. doi: 10.1016/S1474-4422(25)00201-7. PubMed 40683274 ↗

Individual participant data

Plan to share: Yes — If required by journal for publication, the following individual participant data will be entered into a repository: age in years, sex, and outcomes as described above.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 12, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04238260
Responsible party
Janice Eng (Professor, University of British Columbia) — Principal investigator
First posted
Jan 23, 2020
Start date
Apr 25, 2021
Primary completion
Apr 30, 2024
Completion
Apr 30, 2025
Last update
Jun 12, 2026

Study contacts

Janice J Eng, PhD
principal investigator · University of British Columbia

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion