An observational study in Dry Eye Syndrome, Infectious Keratoconjunctivitis and Mucous Membrane Pemphigoid, sponsored by Centre hospitalier de l'Université de Montréal (CHUM). Recruiting at 2 sites in Canada. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-27.
Sponsored by Centre hospitalier de l'Université de Montréal (CHUM) · Observational
This study aims to obtain the lacrimal fingerprint for frequent pathologies of the ocular surface and establish a normative base for each of them.
This is an exploratory study. The investigators aim to:
During regular clinics at the cornea service of the ophthalmology department of the CHUM (Centre Hospitalier de l'Université de Montréal), the investigators aim to recruit a few hundred patients with various pathologies of the ocular surface, notably different forms of dry eye syndrome, infectious keratitis/conjunctivitis, mucous membrane pemphigoid and allergic conjunctivitis, and collect a sample of their tears via Schirmer strip. A case report form will be completed for each patient, noting known ocular diagnoses and active topical ophthalmic medication. Schirmer strips will be sent in sterile tubes to UQAM (Université du Québec à Montréal)'s department of chemistry for analysis by mass spectrometry.
1,366 studies on the registry are indexed under Dry Eye Syndromes; 207 are open to participants now.
This study's planned enrollment of 300 is above the median of 89 across 190 observational studies indexed under Dry Eye Syndromes.
Browse Dry Eye Syndromes studies →Centre hospitalier de l'Université de Montréal (CHUM) is the lead sponsor of 376 studies on the registry; 110 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients consulting at the cornea service of the ophthalmology department of the CHUM.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Dry eye syndrome; Infectious keratitis and/or conjunctivitis; Mucous membrane pemphigoid; Allergic conjunctivitis.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Healthy, normal ocular surface
Diagnostic Test: Tear sample collection via Schirmer strip and subsequent analysis by mass spectrometry
Patients suffering from either: * Lacrimal insufficiency * Anterior blepharitis * Posterior blepharitis * Sjögren syndrome
Diagnostic Test: Tear sample collection via Schirmer strip and subsequent analysis by mass spectrometry
Patients suffering from allergic conjunctivitis
Diagnostic Test: Tear sample collection via Schirmer strip and subsequent analysis by mass spectrometry
Patients suffering from mucous membrane pemphigoid
Diagnostic Test: Tear sample collection via Schirmer strip and subsequent analysis by mass spectrometry
Patients suffering from keratitis and/or conjunctivitis of various etiology: * Viral * Bacterial * Fungal * Acanthamoeba
Diagnostic Test: Tear sample collection via Schirmer strip and subsequent analysis by mass spectrometry
During regular consultations at the ophthalmology department of the CHUM, eligible patients will undergo a standard 5 minute Schirmer tear test. The Schirmer strips will serve as tear samples and will be sent to UQAM's Department of chemistry for mass spectrometry analysis.
To obtain the metabolomic and proteomic fingerprint of the studied ocular surface pathologies
Raw data will be analysed with MarkerView software by Sciex to identify specific over- or under-expressed markers in these ocular pathologies.
Time frame: 5 years
To objectify changes in metabolomic and proteomic profile associated with topical treatments taken by participants in this study
Raw data will be analysed with the same software to identify specific changes in proteomic and/or metabolomic expression associated with the topical treatments taken by participants in this study.
Time frame: 5 years
Not enrolling at this site.
Plan to share: No — The investigators do not plan to share individual participant data.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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