An observational study in Acute Kidney Injury, Chronic Kidney Disease, Stage 3 and Chronic Kidney Disease, Stage 5, sponsored by Seoul National University Hospital. Completed at 1 site in South Korea. Open to participants aged 20 Years and older. Per ClinicalTrials.gov, last updated 2021-10-22.
Sponsored by Seoul National University Hospital · Observational
The investigators aimed to evaluate the association between the duration and stage of acute kidney injury (AKI) and the development of chronic kidney disease during postoperative three years in patients undergoing cardiac or thoracic aortic surgery.
Postoperative acute kidney injury (AKI) has been investigated as an important contributor to postoperative morbidity and mortality after cardiovascular surgery. Also, temporary worsening of renal function after aortic surgery is associated with higher long-term mortality. Although the associations between AKI and chronic kidney disease (CKD) in medical or other surgical settings were reported, only a few studies evaluated this relationship in patients undergoing cardiac surgery. More specifically, the association of the severity or duration of AKI with the risk of the development of new-onset CKD after cardiac surgery has not been clearly elucidated.
It would be important to find predictors of the long-term renal function or risk factors for the development of CKD after cardiac surgery because postoperative management of high-risk patients to develop long-term renal dysfunction may prevent further deterioration in renal function and improve patient prognosis.
The investigators aimed to evaluate (1) the long-term renal function after cardiac surgery and (2) the association between the duration and stage of acute kidney injury (AKI) and the development of chronic kidney disease during postoperative three years in patients undergoing cardiac or thoracic aortic surgery.
1,641 studies on the registry are indexed under Acute Kidney Injury; 380 are open to participants now.
This study's enrollment of 2,009 is above the median of 156 across 795 observational studies indexed under Acute Kidney Injury.
Browse Acute Kidney Injury studies →Seoul National University Hospital is the lead sponsor of 1,897 studies on the registry; 273 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.
Counted across the registry records on this site, refreshed daily.
A retrospective cohort of the adult patients who underwent cardiac or thoracic aortic surgery under cardiopulmonary bypass at Seoul National University Hospital between 2008 and 2017
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
new-onset chronic kidney disease stage 3 or higher or mortality
development of new-onset chronic kidney disease stage 3 or higher or all-cause mortality developed during 3 years after surgery. The new-onset chronic kidney disease was defined by at least two estimated Glomerular Filtration Rate values \<60 ml/min/1.73 m2 separated by an interval of at least three months.
Time frame: during 3 years after surgery
new-onset chronic kidney disease stage 3 or higher or mortality
development of new-onset chronic kidney disease stage 3 or higher or all-cause mortality developed during 1 year after surgery
Time frame: during 1 year after surgery
new-onset chronic kidney disease stage 3 or higher or mortality
development of new-onset chronic kidney disease stage 3 or higher or all-cause mortality developed during 2 years after surgery
Time frame: during 2 years after surgery
Length of postoperative hospital stay
Length of postoperative hospital stay
Time frame: during one month after surgery
Length of postoperative intensive care unit stay
Length of postoperative intensive care unit stay
Time frame: during one month after surgery
intra-aortic balloon pulsation insertion
intra-aortic balloon pulsation insertion
Time frame: during surgery and postoperative one week
Reopen for surgical bleeding
Reopen for surgical bleeding
Time frame: during one month after surgery
Respiratory complication
a composite outcome including postoperative atelectasis, pneumonia, pulmonary edema, pleural effusion and pneumothorax
Time frame: during one month after surgery
in-hospital mortality
all-cause mortality during hospital stay
Time frame: during one month after surgery
Incidence of estimated Glomerular Filtration Rate <60 mL/min/1.73m2
Incidence of estimated Glomerular Filtration Rate \<60 mL/min/1.73m2
Time frame: at three months after surgery
Incidence of estimated Glomerular Filtration Rate <60 mL/min/1.73m2
Incidence of estimated Glomerular Filtration Rate \<60 mL/min/1.73m2
Time frame: at one year after surgery
Incidence of estimated Glomerular Filtration Rate <60 mL/min/1.73m2
Incidence of estimated Glomerular Filtration Rate \<60 mL/min/1.73m2
Time frame: at two years after surgery
Incidence of estimated Glomerular Filtration Rate <60 mL/min/1.73m2
Incidence of estimated Glomerular Filtration Rate \<60 mL/min/1.73m2
Time frame: at three years after surgery
Dependence on the regular hemodialysis
Dependence on the regular hemodialysis
Time frame: at three years after surgery
estimated Glomerular Filtration Rate
estimated Glomerular Filtration Rate
Time frame: at three months after surgery
estimated Glomerular Filtration Rate
estimated Glomerular Filtration Rate
Time frame: at one year after surgery
estimated Glomerular Filtration Rate
estimated Glomerular Filtration Rate
Time frame: at two years after surgery
estimated Glomerular Filtration Rate
estimated Glomerular Filtration Rate
Time frame: at three years after surgery
Plan to share: No
Ran from Nov 2019 to primary completion in Dec 2020, 12 months.
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This study is completed, as verified in Oct 2021. You cannot join it, but the record below documents what was studied.
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