An observational study in Anterior Cruciate Ligament Injuries, sponsored by Umeå University. Completed at 1 site in Sweden. Open to participants aged 15 Years to 35 Years. Per ClinicalTrials.gov, last updated 2026-04-29.
Sponsored by Umeå University · Observational
In this longitudinal prospective cohort study including young people with anterior cruciate ligament (ACL) reconstruction, the investigators will evaluate if poor sensorimotor function at baseline can predict 1) graft rupture 2) the risk of contra-lateral ACL injury and 3) failure to return to sport/previous activity level within 3 years following ACL reconstruction.
In this longitudinal prospective cohort study including young athletic men and women (aged 15-35) with ACL reconstruction (ACLR), it will be investigated if poor sensorimotor function at baseline (1 year post ACLR), such as hop performance, muscle strength and postural orientation can predict 1) graft rupture 2) the risk of contra-lateral ACL injury and 3) failure to return to sport/previous activity level within 3 years following ACLR.
Statistics Separate logistic regression models will be used to elucidate the influence of each muscle sensorimotor function variable on the outcomes (graft rupture, contra-lateral injury, return to sport/activity level failure), adjusted for potential confounders. With the LSI for the single-leg hop test as main outcome, power calculations show that with a re-injury rate of 7%, an estimated odds ratio of 0.95, power=80% and alpha=5 %, at least 174 individuals are needed. Based on this calculation, 200 individuals will be included for the prospective analysis, allowing for an approximate drop-out of 10%.
512 studies on the registry are indexed under Anterior Cruciate Ligament Injuries; 164 are open to participants now.
This study's enrollment of 201 is above the median of 92 across 127 observational studies indexed under Anterior Cruciate Ligament Injuries.
Browse Anterior Cruciate Ligament Injuries studies →Umeå University is the lead sponsor of 263 studies on the registry; 60 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients will be recruited from the Department of Orthopedics, Norrland University hospital, Umeå, Sweden and Skåne University Hospital, Lund, Sweden.
Exclusion Criteria:
Persons who have suffered a unilateral anterior cruciate ligament injury treated with reconstruction
Other: Different measures of muscle function such as muscle strength, hop tests, postural orientation and muscle activation
The participants will be assessed with a physical test battery at baseline including: Isokinetic knee strength, Isometric strength of trunk and lower extremity, Single-leg hop for distance, side hop, postural orientation (single leg-squat, stair descending, forward lunge, Single-leg hop for distance, side-hop), hip and ankle range of joint motion, muscular activation pattern, 3D movement analysis and proprioception test. At follow-up (2 years), the participants will be asked to answer a survey about new ACL injuries and return to sport/previous activity level.
Number of participants with graft rupture
Number of patients that have sustained a rupture of the reconstructed ligament
Time frame: 2 years
Number of patients with contra-lateral ACL injury
Number of patients that have sustained an injur to the contra-lateral knee
Time frame: 2 years
Failure to return to sport/previous activity level
Number of patients that had failed to return to previous sport/activity level
Time frame: 2 years
Plan to share: Undecided
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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Anterior Cruciate Ligament Injuries→
Umeå University