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RecruitingNCT04113486ENRCUpdated Jul 29, 2026

Expression Levels of Nicotinamide Metabolism-related Protein (NMAP) in Newly Diagnosed Renal Cancer and Non-renal Cancer Populations

An observational study in Carcinoma, Renal Cell, sponsored by Xinhua Hospital, Shanghai Jiao Tong University School of Medicine. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-29.

Sponsored by Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Observational

From the registry’s dates

  • Started Oct 2019; still recruiting 7 years later.
Study type
Observational
Model
Other
Time perspective
Cross-sectional
Enrollment
400
Ages
18 Years and older
Sex
All
01

Study summary

This study aims to observe the difference between NMAP (nicotinamide metabolism associated protein) serum levels in primary diagnosed renal cancer patients and non-renal cancer patient controls, plot the ROC curve and establish appropriate cut-off values.

02

Conditions studied

  • Carcinoma, Renal Cell

Keywords

  • renal cancer
  • tumor biomarker
03

In context

Carcinoma, Renal Cell

1,965 studies on the registry are indexed under Carcinoma, Renal Cell; 378 are open to participants now.

This study's planned enrollment of 400 is above the median of 146 across 360 observational studies indexed under Carcinoma, Renal Cell.

Browse Carcinoma, Renal Cell studies →

Lead sponsor

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine is the lead sponsor of 222 studies on the registry; 54 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Sampling method
Non-probability sample

Study population

All patients are in-hospital patients treated in Xinhua Hospital

Inclusion criteria

  1. The tumor group patients were found to have renal or hepatic mass, plan to receive surgical treatment (except for radiofrequency ablation, cryoablation, etc., which were not available for pathological examination). The control group patients were ruled out of tumor based on radiological tests and commonly used tumor biomarkers
  2. Age ≥ 18 years old and able to provide written informed consent;
  3. Have not received any systemic or topical treatment for kidney/liver tumors.
  4. Cardiopulmonary, liver and kidney functions are able to tolerate surgery and can comply with research requirements.

Exclusion criteria

Exclusion Criteria:

  1. The investigators believe that the subject may be unsuitable for inclusion due to severe concurrent diseases, infections, and etc.
  2. The subjects is known or suspected of other malignancies.
  3. There has been another history of malignancy in the past 5 years.
  4. Major surgery (surgery requiring general anesthesia) was performed within 4 weeks prior to screening visits.
05

Study design

Observational model
Other
Time perspective
Cross-sectional
Enrollment
400 participants (estimated)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • Renal cancer group

    Patients which imaging studies have found renal mass, plan to receive surgery (except for radiofrequency ablation, cryoablation, etc.), about 100.

    Other: Blood test

  • Urothiasis group

    Patients which imaging studies have found renal or ureteral stones, and rule out of renal mass, about 100.

    Other: Blood test

  • Renal cysts group

    Patients which imaging studies have found renal cysts (simple or complex) about 100.

    Other: Blood test

  • Liver cancer group

    Patients which imaging studies have found hepatic mass, plan to receive surgery (except for radiofrequency ablation, cryoablation, etc.), about 100.

    Other: Blood test

Interventions

  • OtherBlood test

    About 4 ml of blood draw

06

What researchers measure

Primary outcomes

  1. NMAP level study

    To observe the difference in the expression level of nicotinamide metabolism related protein (NMAP) in the serum of newly diagnosed renal cancer and non-renal cancer patients. Draw the NMAP ROC curve and establish the appropriate Cut-off value to analyze its sensitivity and specificity.

    Time frame: September 2019-September 2021

Secondary outcomes

  1. NMAP plus other tumor biomarkers study

    According to NMAP and combined with other tumor biomarkers data such as AFP, multiple regression analysis was used to map the ROC curve and establish the appropriate Cut-off value to determine whether it is capable of distinguishing kidney cancer and liver cancer.

    Time frame: September 2019-September 2021

07

Study locations

1 of 1 sites recruiting
  • Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine
    Shanghai, Shanghai Municipality 200092, China
    Recruiting
08

References and documents

Individual participant data

Plan to share: No — No plan to reveal IPD due to further research plan

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 29, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04113486
Lead sponsor
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Responsible party
Jie Ding (Attending doctor, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine) — Principal investigator
First posted
Oct 2, 2019
Start date
Oct 1, 2019
Primary completion
Jan 30, 2029 (estimated)
Completion
Jan 30, 2030 (estimated)
Last update
Jul 29, 2026

Study contacts

Min NA Shi, MD
Contact
shimin@xinhuamed.com.cn
021-25076143

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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