An observational study in Intracerebral Hemorrhage and Subarachnoid Hemorrhage, sponsored by University of Leipzig. Completed at 10 sites in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-05.
Sponsored by University of Leipzig · Observational
The aim of the observational multicenter trial encompasses the comparison of estimation of the long-term prognosis (functional and cognitive outcomes, quality of life) after intracerebral and subarachnoid hemorrhages assessed by clinical scores, treating physicians and nurses. The scores and the assessment of the treating physicians and nurses are recorded on admission, at 7 and 14 days after symptom onset.
The physicians and nurses responsible for the individual patient's care will be given a questionaire. They are asked to estimate the functional and cognitive status as well as quality of life of their patient. The patient with intracerebral hemorrhage and subarachnoid hemorrhage is examined and assessed with respective established and validated prognostic scores and models at the same time points.
The actual prognosis is assessed by telephone interview and questionaires at 3 and 6 months, either from the patient or his/her caretaker.
476 studies on the registry are indexed under Cerebral Hemorrhage; 181 are open to participants now.
This study's enrollment of 1,085 is above the median of 275 across 180 observational studies indexed under Cerebral Hemorrhage.
Browse Cerebral Hemorrhage studies →University of Leipzig is the lead sponsor of 147 studies on the registry; 24 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All patients admitted with acute spontaneous intracerebral and nontraumatic subarachnoid hemorrhage to a center with neurocritical care expertise
Exclusion Criteria:
assessment at different time points
Modified Rankin Scale dichotomized 0-2 versus 3-6 at 6 months
Modified Rankin Scale dichotomized 0-2 (good functional outcome) versus 3-6 (poor functional outcome)
Time frame: 6 months
Modified Rankin Scale dichotomized 0-2 versus 3-6 at 3 months
Modified Rankin Scale dichotomized 0-2 (good functional outcome) versus 3-6 (poor functional outcome)
Time frame: 3 months
Modified Rankin Scale dichotomized 0-3 versus 4-6 at 6 months
Modified Rankin Scale dichotomized 0-3 (good functional outcome) versus 4-6 (poor functional outcome)
Time frame: 6 months
Modified Rankin Scale dichotomized 0-3 versus 4-6 at 3 months
Modified Rankin Scale dichotomized 0-3 (good functional outcome) versus 4-6 (poor functional outcome)
Time frame: 3 months
Quality of life measured by Short Form Health Survey Short Form (SF)-36
Short Form Health Survey Short Form (SF)-36: Out of the 36 items, the following 8 subscales/dimensions are assessed and compared to the values of the normal Population: physical function (10 items), physical role function (4 items), physical pain (2 items), general perception of health status (5 items), vitality (4 items), social function and Integration (2 items), emotional role functioning (3 items), psychological well-being (5 items), Change of health status, compared to one year ago (1 item). The first 4 dimensions can be summarized to the physical sum scale, the second 4 items comprise the psychological sum scale.
Time frame: 3 and 6 months
Quality of life measured by Sickness Impact Profile
Sickness Impact Profile: 189 items in 14 topic categories. The physical dimension score is obtained by adding the scale values for each item checked within categories body care and movement, mobility, and ambulation, dividing by the maximum possible dysfunction score for these categories, and then multiplying by 100; the psychosocial dimension score is obtained by adding the scale values for each item checked within categories emotional behavior, social interaction, alterness behavior, and communication, dividing by the maximum possible dysfunction score for these categories, and then multiplying by 100. The scores for the remaining categories are always calculated individually. The overall score for the SIP is calculated by adding the scale values for each item checked across all categories and dividing by the maximum possible dysfunction score for the SIP. This figure is then multiplied by 100 to obtain the SIP overall score.
Time frame: 3 and 6 months
Cognitive outcome Telephone Interview for Cognitive Status
Telephone Interview for Cognitive Status: During the telephone interview scores for 22 questions are obtained and added to a total score. The qualitative interpretive ranges are 33-41: cognitive impairment unlikely; 26-32 cognitive impairment may be or may not be present dependent on patients's age, education, history, etc.; 21-25: mild cognitive impairment; \</=20: moderate to severe cognitive impairment.
Time frame: 3 and 6 months
Plan to share: No
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This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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University of Leipzig