An observational study in Congenital Heart Disease and Acute Kidney Injury, sponsored by Huiying Shao. Completed at 1 site in China. Open to participants aged 1 Minute to 3 Years. Per ClinicalTrials.gov, last updated 2019-10-21.
Sponsored by Huiying Shao · Observational
This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.
Acute kidney injury is one of the major complications after heart surgery, which increases the mortality of patients. Therefore, early prevention and detection of acute kidney injury is particularly important. In recent years, more and more studies have shown that both sevoflurane, an inhaled anesthetic widely used in clinical practice, and propofol, an intravenous anesthetic, have protective effects on kidneys. The aim of this study was to investigate the perioperative effects of two different anesthetic techniques on renal function for pediatric cardiac surgery.
1,595 studies on the registry are indexed under Acute Kidney Injury; 371 are open to participants now.
This study's enrollment of 60 is below the median of 150 across 773 observational studies indexed under Acute Kidney Injury.
Browse Acute Kidney Injury studies →This is the only study on the registry with Huiying Shao as lead sponsor.
Counted across the registry records on this site, refreshed daily.
After approved by the ethics committee, sixty patients who met the inclusion criteria of this study with their parents' informed consent in Children's Hospital of Fudan University.
Exclusion Criteria:
sevoflurane (1-3%)and sufentanil (0.5-2 mcg/kg/h) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required
Other: inhalation anesthesia
propofol (4-12 mg/kg/h) and sufentanil (0.5-2 mcg/kg/h/) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required
Other: Total intravenous anesthesia
sevoflurane was used to maintain anesthesia
propofol was used to maintain anesthesia
renal blood flow
Changes of blood flow information of renal artery was obtained before anesthesia induction, after anesthesia, at the end of operation and 24 hours after surgery, unit(cm/s)
Time frame: 2 days
neutrophil gelatinase-associated lipocalin , NGAL
Changes of blood NGAL were obtained before and 2 hours after surgery, unit(ng/ml)
Time frame: 2 days
creatinine
Changes of creatinine before and 3 days after acquisition, unit (mmol/L)
Time frame: 3 and 4 days
Mean arterial pressure
Mean arterial pressure synchronized with renal blood flow was recorded, unit (mmHg)
Time frame: 2 days
cardiopulmonary bypass (CPB) time
Cardiopulmonary bypass time was recorded, unit(minutes)
Time frame: 24 hours
This study is completed, as verified in Oct 2019. You cannot join it, but the record below documents what was studied.
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