An interventional study of Motivational Interviewing in Cystic Fibrosis, sponsored by Belfast Health and Social Care Trust. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-07-12.
Sponsored by Belfast Health and Social Care Trust · Not applicable, Interventional, and Supportive care
Adherence to treatment is a major challenge in cystic fibrosis (CF). Motivational Interviewing (MI) is increasingly used to address this, but its effectiveness is unknown. We investigated the clinical impact of an MI intervention, delivered by a specifically trained pharmacist, on adherence to inhaled antibiotics (IA).
Adherence to treatment is a major challenge in cystic fibrosis (CF). Motivational Interviewing (MI) is increasingly used to address this, but its effectiveness is unknown. We investigated the clinical impact of an MI intervention, delivered by a specifically trained pharmacist, on adherence to inhaled antibiotics (IA).
Adults with CF were recruited through the Regional CF Centre. A pharmacist trained in MI delivered three recorded MI sessions over 2 months, with follow up at 3, 4 and 6 months. Demographics, ppFEV1, BMI, adherence (IA collection rates) and additional antibiotic use were collected during the study and for 6 months prior. Treatment Quality and Satisfaction (TQSM), self-reported adherence (Moriskey Medication Adherence Scale-8 (MMAS-8)), Quality Of Life (CF Questionnaire-Revised (CFQ-R)) and sputum Pseudomonas aeruginosa (Pa) density were assessed at each study visit. Statistical analysis compared outcomes pre and post-intervention and variation during the intervention period.
1,581 studies on the registry are indexed under Cystic Fibrosis; 190 are open to participants now.
This study's enrollment of 22 is below the median of 36 across 1,034 interventional studies indexed under Cystic Fibrosis.
Browse Cystic Fibrosis studies →Belfast Health and Social Care Trust is the lead sponsor of 43 studies on the registry; 7 are open to participants now.
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Exclusion Criteria:
All participants were entered into the intervention cohort to receive the Motivational Interviewing intervention
Behavioral: Motivational Interviewing
A pharmacist trained in MI delivered three recorded MI sessions over 2 months, with follow up at 3, 4 and 6 months.
Inhaled Antibiotic collection percentage
Change in adherence to Inhaled Antibiotic measured by collection from pharmacy in 6 months before intervention and at end of intervention
Time frame: 6 months preceding intervention compared to end of 6 month intervention period
Percent Predicted Forced Expiratory Volume in 1 second (ppFEV1)
Change in ppFEV1 from start of study to end of study (6 months)
Time frame: 6 months
Body Mass Index (BMI)
Change in BMI from start of study to end of study (6 months)
Time frame: 6 months
Need for additional Intra-venous or oral antibiotics
change in additional antibiotic days from 6 months preceding the intervention to end of intervention period
Time frame: 6 months
Treatment quality and satisfaction (TQSM)
Change in TQSM from start to end of intervention period
Time frame: 6 months
Self reported adherence using "Moriskey Medication Adherence 8" questionnaire (MMAS-8)
Change in MMAS-8 from start to end of intervention period
Time frame: 6 months
Density of Pseudomonas growth in sputum
Change in density of pseudomonas growth from start to end of intervention period
Time frame: 6 months
Quality of life measured by CFQ-R
Change in quality of life from start to end of intervention period
Time frame: 6 months
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.
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Belfast Health and Social Care Trust