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TerminatedNCT03936595PoTrRecUpdated Jan 5, 2021

Recovery of Performance, Muscle Damage and Neuromuscular Fatigue Following Muscle Power Training

An interventional study of Core exercises protocol and Structural exercises protocol in Power Training Exercise Protocols, sponsored by University of Thessaly. Terminated at 1 site in Greece. Open to male participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-01-05.

Sponsored by University of Thessaly · Not applicable, Interventional, and Treatment

Why this study was terminated
There was a high drop-out rate and we were unable to recruit new subjects.
Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
Male
01

Study summary

Muscle power is one of the most important parameters in almost every athletic action, and expresses the ability of the human muscle to produce great amounts of force with the greatest possible speed. Thus, muscle power is critical for high performance in athletic actions such as jumping, throwing, change of direction and sprinting. For enhancing their muscle power, athletes comprise several resistance training programs as part of their training. Muscle power training comprises of eccentric muscle actions, and the magnitude of these actions depend on the emphasis that is given on the concentric or eccentric action, respectively, of the muscles during the exercises. However, eccentric muscle action, especially when unaccustomed, can lead to exercise-induced muscle damage (EIMD), and deterioration of muscle performance.

Despite the fact that muscle power training comprises eccentric muscle actions, and consequently can lead to muscle injury and muscle performance reduction during the following days, the recovery kinetics after acute muscle power training have not been adequately studied. However, information regarding the recovery of the muscles after a power training protocol, is critical for the correct design of a training microcycle, and the reduction of injury risk.

The aim of the present study is to investigate the muscle injury provoked after acute muscle power training using three different power training exercise protocols. Additionally, we will examine the effect of these protocols on muscle performance and neuromuscular fatigue indices.

Read the detailed description

Muscle power is one of the most important parameters in almost every athletic action, and expresses the ability of the human muscle to produce great amounts of force with the greatest possible speed. Thus, muscle power is critical for high performance in athletic actions such as jumping, throwing, change of direction and sprinting.

For enhancing their muscle power, athletes comprise several resistance training programs as part of their training. Core exercises as long as Olympic lifting has been used in muscle power training. The loads that are applied regarding the accomplishment of the most favorable power production are varying. Training load of 0% 1RM favored power production at the countermovement squat jump, while loads of 56% 1rm and 80% 1RM, favored the power production at squat and hang clean, respectively. Additionally, In the recent years, accentuated eccentric training has been proposed as a new training method for the enhancement of muscle power. This method emphasizes the eccentric component of the muscle contraction, and there is evidence supporting the greater production of muscle force after accentuated eccentric training compared with the typical resistance exercise training method.

Taking the above into consideration, muscle power training comprises of eccentric muscle actions, and the magnitude of the eccentric component depends on the emphasis that is given on the concentric or eccentric action, respectively, of the muscles during the exercises. However, eccentric muscle action, especially when unaccustomed, can lead to exercise-induced muscle damage (EIMD). Although concentric and isometric exercise may also lead to muscle injury, the amount of damage after eccentric muscle contractions is greater. EIMD, amongst others, is accompanied by increased levels of creatine kinase (CK) into the circulation, increased delayed onset of muscle soreness (DOMS), reduction of force production, reduction of flexibility speed.

Despite the fact that muscle power training comprises eccentric muscle actions, and consequently can lead to muscle injury and muscle performance reduction during the following days, the recovery kinetics after acute muscle power training protocols have not been adequately studied. However, information regarding the recovery of the muscles after a power training protocol, is critical for the correct design of a training microcycle, and the reduction of injury risk.

The aim of the present study is to investigate the muscle injury provoked after muscle acute power training using three different power training exercise protocols. Additionally, the effect of these protocols on muscle performance and neuromuscular fatigue indices will be examined.

02

Conditions studied

  • Power Training Exercise Protocols

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03

In context

Fatigue

1,863 studies on the registry are indexed under Fatigue; 377 are open to participants now.

This study's enrollment of 10 is below the median of 54 across 1,443 interventional studies indexed under Fatigue.

Browse Fatigue studies →

Lead sponsor

University of Thessaly is the lead sponsor of 188 studies on the registry; 44 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • No recent history of musculoskeletal injury
  • No use of ergogenic supplements and drugs
  • No use of anti-inflammatory and antioxidant supplements (> 6 months)
  • No participation at intense eccentric exercise for at least 3 days before protocols

Exclusion criteria

Exclusion Criteria:

  • Recent history of musculoskeletal injury
  • Use of ergogenic supplements and drugs
  • Use of anti-inflammatory and antioxidant supplements (\< 6 months)
  • Participation at intense eccentric exercise for at least 3 days before protocols
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
10 participants (actual)

Study arms

  • Experimental
    Core exercises protocol

    Participants will perform 4 core exercises

    Other: Core exercises protocol

  • Experimental
    Structural exercises protocol

    Participants will perform 4 structural (Olympic lifting) exercises

    Other: Structural exercises protocol

  • Experimental
    Accentuated eccentric load exercises protocol

    Participants will perform 4 exercises with eccentric loading

    Other: Accentuated eccentric load exercises protocol

  • Other
    Control condition

    Participants will perform all the measurements that are comprised in the experimental conditions without performing any exercise protocol

    Other: Control condition

Interventions

  • OtherCore exercises protocol

    Participants will perform: 1. Squats, 4 sets of 5 repetitions at 60% 1RM 2. Deadlifts, 4 sets of 5 repetitions at 60% 1RM 3. Lunges, 4 sets of 5 repetitions at 60% 1RM 4. Step ups, 4 sets of 5 repetitions at 60% 1RM

  • OtherStructural exercises protocol

    Participants will perform: 1. Snatch, 4 sets of 5 repetitions at 60% 1RM 2. Hang clean, 4 sets of 5 repetitions at 60% 1RM 3. Push jerk, 4 sets of 5 repetitions at 60% 1RM 4. Split push jerk, 4 sets of 5 repetitions at 60% 1RM

  • OtherAccentuated eccentric load exercises protocol

    Participants will perform: 1. Deadlifts - squat jump, 4 sets of 5 repetitions at 30% body mass (BM) 2. Step down - squat jump, 4 sets of 5 repetitions at 30% BM 3. Step down - lunges, 4 sets of 5 repetitions at 30% BM 4. Hip thrusts, 4 sets of 5 repetitions at 30% BM

  • OtherControl condition

    Participants will perform all the measurements that are comprised in the experimental conditions without performing any exercise protocol

06

What researchers measure

Primary outcomes

  1. Change on delayed onset of muscle soreness (DOMS), in the knee flexors (KF) and extensors (KE) of both limbs

    Participants will perform three repetitions of a full squat movement, and rate their soreness level in knee flexors and extensors on a visual analog scale from 1 to 10 (VAS, with "no pain" at one end and "extremely sore" at the other), using palpation of the belly and the distal region of relaxed knee extensors and flexors.

    Time frame: Prior to, immediately after, 1, 2, 3 days after the end of the experimental protocol

  2. Change on countermovement jump (CMJ) height

    CMJ height will be measured in 3 maximal efforts (the best jump will be recorded) on an Ergojump contact platform

    Time frame: Prior to, immediately after, 1, 2, 3 days after the end of the experimental protocol

  3. Change on isometric peak torque of the knee extensors (KE)

    Isometric peak torque of the KE will be measured on an isokinetic dynamometer at 60◦/sec

    Time frame: Prior to, immediately after, 1, 2, 3 days after the end of the experimental protocol

  4. Change on isometric peak torque of the knee flexors (KF)

    Isometric peak torque of the KF will be measured on an isokinetic dynamometer at 60◦/sec

    Time frame: Prior to, immediately after, 1, 2, 3 days after the end of the experimental protocol

  5. Change on concentric isokinetic peak torque of the knee extensors (KE)

    Concentric peak torque of the KE will be measured on an isokinetic dynamometer at 60◦/sec

    Time frame: Prior to, immediately after, 1, 2, 3 days after the end of the experimental protocol

  6. Change on concentric isokinetic peak torque of the knee flexors (KF)

    Concentric peak torque of the KF will be measured on an isokinetic dynamometer at 60◦/sec

    Time frame: Prior to, immediately after, 1, 2, 3 days after the end of the experimental protocol

  7. Change one eccentric isokinetic peak torque of the knee extensors (KE)

    Eccentric peak torque of the KE will be measured on an isokinetic dynamometer at 60◦/sec

    Time frame: Prior to, immediately after, 1, 2, 3 days after the end of the experimental protocol

  8. Change on eccentric isokinetic peak torque of the knee flexors (KF)

    Eccentric peak torque of the KF will be measured on an isokinetic dynamometer at 60◦/sec

    Time frame: Prior to, immediately after, 1, 2, 3 days after the end of the experimental protocol

  9. Change on the concentration of plasma CK activity

    Plasma CK activity will be measured with a biochemical analyzer

    Time frame: Prior to, immediately after, 1, 2, 3 days after the end of the experimental protocol

  10. Change on the concentration of blood lactate

    Lactate will be measured with a portable lactate analyzer using capillary blood

    Time frame: Prior to, and immediately after the end of the experimental protocol

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Study locations

1 site
  • Laboratory of Exercise Biochemistry, Exercise Physiology,and Sports Nutrition, School of Physical Education and Sport Science, University of Thessaly
    Trikala, Thessaly 42100, Greece
08

References and documents

Publications

  • Cormie P, McCaulley GO, Triplett NT, McBride JM. Optimal loading for maximal power output during lower-body resistance exercises. Med Sci Sports Exerc. 2007 Feb;39(2):340-9. doi: 10.1249/01.mss.0000246993.71599.bf. PubMed 17277599 ↗
  • Baird MF, Graham SM, Baker JS, Bickerstaff GF. Creatine-kinase- and exercise-related muscle damage implications for muscle performance and recovery. J Nutr Metab. 2012;2012:960363. doi: 10.1155/2012/960363. Epub 2012 Jan 11. PubMed 22288008 ↗
  • Deli CK, Fatouros IG, Paschalis V, Georgakouli K, Zalavras A, Avloniti A, Koutedakis Y, Jamurtas AZ. A Comparison of Exercise-Induced Muscle Damage Following Maximal Eccentric Contractions in Men and Boys. Pediatr Exerc Sci. 2017 Aug;29(3):316-325. doi: 10.1123/pes.2016-0185. Epub 2017 Feb 6. PubMed 28165870 ↗
  • Jamurtas AZ, Theocharis V, Tofas T, Tsiokanos A, Yfanti C, Paschalis V, Koutedakis Y, Nosaka K. Comparison between leg and arm eccentric exercises of the same relative intensity on indices of muscle damage. Eur J Appl Physiol. 2005 Oct;95(2-3):179-85. doi: 10.1007/s00421-005-1345-0. Epub 2005 Jul 9. PubMed 16007451 ↗
  • Kyrolainen H, Avela J, McBride JM, Koskinen S, Andersen JL, Sipila S, Takala TE, Komi PV. Effects of power training on muscle structure and neuromuscular performance. Scand J Med Sci Sports. 2005 Feb;15(1):58-64. doi: 10.1111/j.1600-0838.2004.00390.x. PubMed 15679573 ↗
  • Walker S, Blazevich AJ, Haff GG, Tufano JJ, Newton RU, Hakkinen K. Greater Strength Gains after Training with Accentuated Eccentric than Traditional Isoinertial Loads in Already Strength-Trained Men. Front Physiol. 2016 Apr 27;7:149. doi: 10.3389/fphys.2016.00149. eCollection 2016. PubMed 27199764 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 5, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03936595
Lead sponsor
University of Thessaly
Responsible party
Ioannis G. Fatouros (Professor, University of Thessaly) — Principal investigator
First posted
May 3, 2019
Start date
May 6, 2019
Primary completion
Jun 16, 2019
Completion
Jun 28, 2019
Last update
Jan 5, 2021

Study contacts

Ioannis G Fatouros, PhD
principal investigator · University of Thessaly

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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