An observational study in Weaning Mechanical Ventilation, sponsored by University of Thessaly. Recruiting at 3 sites in Greece. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-02.
Sponsored by University of Thessaly · Observational
Failure of liberation from mechanical ventilation increases days spent being mechanically ventilated, the length of stay and the morbidity of patients. Thus it is crucial that those patients who are ready to be liberated are accurately detected. In this study the investigators want to externally validate an index (the volume-velocity index, VVI) which in a preliminary study was found to predict with high accuracy the outcome of ventilator liberation.
In this study, in patients who are deemed ready to undergo weaning by their treating physician the investigators will measure the excursion of the diaphragm, the principal respiratory muscle, the inspiratory time and the tidal volume and the volume breathed by the patient at each respiration in three phases:
The investigators will evaluate whether VVI can predict accurately the weaning outcome.
University of Thessaly is the lead sponsor of 195 studies on the registry; 44 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Critical Care patients undergoing weaning from mechanical ventilation
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Weaning outcome
Validate the predictive capability of VVI for weaning outcome
Time frame: From the start of the spontaneous breathing trial to failure or success at 48 hours after exubation.
VVI for SBT or extubation
Comparison of the capability of VVI to predict SBT or extubation failure
Time frame: From the start of the spontaneous breathing trial to failure or success at 48 hours after exubation.
VVI vs RSBI
Comparison of the predictive capability of VVI with RSBI for weaning outcome
Time frame: From the start of the spontaneous breathing trial to failure or success at 48 hours after exubation.
Predictive capability of VVI between long or short ventilation time
Comparison of the redictive capability of VVI between patients ventilated for more than 7 days with patients ventilated for less than 7 days
Time frame: From the start of the spontaneous breathing trial to failure or success at 48 hours after exubation.
VVI in various SBT modalities
Compare the ability of VVI to predict the weaning outcome in various SBT modalities, namely Pressure Support 8/0 and Pressure Support 5/5 versus t-tube or Pressure Support 0/0
Time frame: From the start of the spontaneous breathing trial to failure or success at 48 hours after exubation.
Relationship of VVI with MIP and MRC
evaluate the relationship of VVI with indices of strength status such as the maximal inspiratory pressure, for the respiratory muscles, and the medical research council score, for the ICU acquired weakness.
Time frame: From the start of the spontaneous breathing trial to failure or success at 48 hours after exubation.
Plan to share: No
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