An interventional study of lung ultrasound in Ventilator Associated Pneumonia, sponsored by Tribhuvan University Teaching Hospital, Institute Of Medicine.. Completed at 1 site in Nepal. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-04-17.
Sponsored by Tribhuvan University Teaching Hospital, Institute Of Medicine. · Not applicable, Interventional, and Diagnostic
The study evaluates whether lung ultrasound monitoring could lead to earlier detection of ventilator associated pneumonia and influence outcome. Half of the participants will be diagnosed with VAP using a combination of lung ultrasound and clinical features and half will be diagnosed using the Johanson criteria, which is a combination of clinical features and chest x-ray.
The current guidelines recommend the use of chest x-ray or computed tomography of the chest to aid in the diagnosis of VAP. However many studies have shown that chest x-ray is neither very sensitive nor specific for pneumonia, and computed tomography, though has the highest diagnostic accuracy, is not routinely performed due to logistics, safety concerns, economics and radiation exposure.
Emerging studies including meta-analyses have shown high sensitivity and specificity of lung ultrasound in diagnosing pneumonia. When combined with clinical and microbiological features it has shown to be helpful in early diagnosis of VAP, but a study to show whether such early detection improves outcome is lacking.
2,044 studies on the registry are indexed under Pneumonia; 283 are open to participants now.
This study's enrollment of 88 is below the median of 106 across 1,247 interventional studies indexed under Pneumonia.
Browse Pneumonia studies →Tribhuvan University Teaching Hospital, Institute Of Medicine. is the lead sponsor of 40 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients will be monitored for ventilator associated pneumonia using lung ultrasound combined with clinical features
Diagnostic Test: lung ultrasound
Patients will be monitored for ventilator associated pneumonia using chest x-ray and clinical features.
lung ultrasound will be performed daily in mechanically ventilated patients after 48 hours of ventilation to screen for ventilator associated pneumonia
ventilator free days
number of days alive from day 1 (of VAP) to day 28 on which a patient breathes without assistance, if the period of unassisted breathing lasted at least 48 consecutive hours. If death occurs within 28 days then ventilator free days is counted as 0
Time frame: day 28 from diagnosis of VAP
icu mortality
death during icu stay
Time frame: through study completion, an average of 3 months
icu length of stay
total duration of stay in icu
Time frame: through study completion, an average of 3 months
delta sofa
change in Sequential Organ Failure Score (SOFA) at day 4 of onset of VAP from the day of onset of VAP. SOFA ranges from 0 to 24. Delta sofa is the difference between SOFA score at day 4 from day 0 of VAP diagnosis. the higher the difference, the better the outcome
Time frame: day 4 from VAP diagnosis
ventilator days
total days the patient remains in mechanical ventilation
Time frame: day 28 from intubation
antibiotic duration
total days the patient receives antibiotics for VAP
Time frame: day 14 from initiation of antibiotic
Plan to share: Yes — all data
Supporting information: Study protocol, Sap, Icf, Csr
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2019. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Tribhuvan University Teaching Hospital, Institute Of Medicine.