An interventional study of Iodine capsule and Iodized Salt in Iodine Deficiency Goiter and Infant Development, sponsored by Oklahoma State University. Completed at 1 site in Ethiopia. Open to female participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-03-26.
Sponsored by Oklahoma State University · Not applicable, Interventional, and Treatment
This study evaluated efficacy of iodized salt for mothers and their six-month-old infants' thyroid hormones and visual information processing. Half of the participants received 450 g iodized salt for the household each week, while the other half received 225 ug iodine daily as a potassium iodide capsule.
Iodine is essential for the synthesis of thyroid hormones, and thyroid hormones regulate the metabolic processes of most cells and play important roles in human growth and development. Iodine deficiency disorders can have serious consequences on brain and physical development. In neonates iodine deficiency and hence insufficient supply of thyroid hormones could cause neonatal goiter, neonatal hypothyroidism, and endemic mental retardation.
Iodine deficiency disorders can be prevented and controlled by providing iodine and iodine can be provided in different ways. However, the United Nations Children's Fund and the World Health Organization jointly recommended salt iodization where iodized salt is accessible. Iodized salt is a safe, cost effective and sustainable strategy to ensure sufficient intake of iodine by all individuals and to improve maternal and infant health. However, although the effect of iodine on human health is well established efficacy of iodized salt has not been studied.
66 studies on the registry are indexed under Goiter; 11 are open to participants now.
This study's enrollment of 106 is close to the median of 100 across 42 interventional studies indexed under Goiter.
Browse Goiter studies →Oklahoma State University is the lead sponsor of 39 studies on the registry; 4 are open to participants now.
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Exclusion Criteria:
Group one received iodine capsule
Dietary Supplement: Iodine capsule
Group two received iodized salt
Other: Iodized Salt
225 µg of iodine daily as a capsule of potassium iodide
450 g iodized salt provided for the household weekly. Salt iodine content was 30 to 40 mg iodine /kg salt as KIO3
Change from baseline breast milk iodine concentration (µg/L) at six months
Laboratory analysis
Time frame: First week after delivery and at six months
Change from baseline urinary iodine concentration (µg/L at six months
Laboratory analysis
Time frame: First week after delivery and at six months
Change from baseline Infants' anthropometric measurement (Z-score) at six months
Measurement
Time frame: First week after delivery and at six months
Change from baseline thyroid hormones status at six months
Laboratory analysis
Time frame: First week after delivery and at six months
Infants' visual information processing
Looking behavior test
Time frame: At six months after delivery
Plan to share: No
Ran from Jan 2013 to primary completion in Jan 2013, 0 months.
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This study is completed, as verified in Mar 2019. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Iodine
Oklahoma State University