An interventional study of Subglottic secretion lavage combined with aspiration and Subglottic secretion aspiration in Ventilator Associated Pneumonia, sponsored by The First Hospital of Jilin University. Status unknown. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2019-03-12.
Sponsored by The First Hospital of Jilin University · Not applicable, Interventional, and Prevention
The purpose of this study is to determine the efficacy of intermittent subglottic secretion lavage combined with aspiration preventing ventilator associated pneumonia in patients with severe neurological disease
Ventilator-associated pneumonia (VAP) is a common and serious complication of mechanical ventilation. Many studies have shown that the accumulation of subglottic secretions above the endotracheal cuff plays an important role in the pathogenesis of VAP. Subglottic secretion drainage (SSD) has been shown to be associated with a lower incidence of VAP in previous meta-analyses. Most studies in past reported that in the group of patients in whom endotracheal tube (ETT) was used and subglottic secretion drainage was applied compared to the group without subglottic secretion drainage.Very few studies compared two different methods of SSD,such as subglottic secretion lavage combined with aspiration or pure aspiration.The tubes need frequent cleaning as they often get blocked, especially the draining duct. This may be the reason why they are not commonly applied. However,subglottic secretion lavage combined with aspiration can reduce the incidence of tube blockage.So The purpose of this study is to determine the efficacy of intermittent subglottic secretion lavage combined with aspiration preventing ventilator associated pneumonia in patients with severe neurological disease.
2,044 studies on the registry are indexed under Pneumonia; 283 are open to participants now.
This study's planned enrollment of 234 is above the median of 106 across 1,247 interventional studies indexed under Pneumonia.
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Exclusion Criteria:
Intermittent subglottic secretions lavage combined with aspiration
Procedure: Subglottic secretion lavage combined with aspiration
Intermittent subglottic secretions aspiration
Procedure: Subglottic secretion aspiration
Ventilator-associated pneumonia preventive measures were applied to all patients according to VAP bundle. Subglottic secretion lavage combined with aspiration was performed every 4 hours: Underwent preoxygenation before cuff pressure checking, and was maintained between 30 and 35 cmH2O. After aspirating secretions from the mouth, nose, and airway, 2-5 mL distilled sterile water was instilled through the subglottic lumen, and then the negative pressure suction device is connected with the outer opening of the side cavity of endotracheal intubation for suction with a negative pressure of 100 mmHg, and each suction was kept under 15 seconds. Repeat lavage and aspiration until the irrigation fluid is clear. After washing, cuff pressure checking and was maintained between 25 and 30 cmH2O.
Ventilator-associated pneumonia preventive measures were applied to all patients according to VAP bundle. Subglottic secretion aspiration was performed every 4 hours:Underwent preoxygenation before cuff pressure checking ,and was maintained between 25 and 30 cmH2O. After aspirating secretions from the mouth, nose, and airway, the negative pressure suction device is connected with the outer opening of the side cavity of endotracheal intubation for suction with a negative pressure of 100 mmHg, and each suction was kept under 15 seconds. Repeat suction until the secretion is completely absorbed.
Incidence of ventilator-associated pneumonia
is pneumonia that occurs when an artificial airway is established and mechanically ventilated
Time frame: through study completion, an average of 10 months
Incidence of draining duct blockage
If mucus flow stopped during subglottic suctioning with a sudden increase of the negative pressure in the proximal port of the suction suggesting a probable occlusion
Time frame: through study completion, an average of 10 months
length of mechanical ventilation
length of mechanical ventilation
Time frame: through study completion, an average of 10 months
The coincidence rate between pathogens of subglottic secretions and the lower respiratory tract
The coincidence rate between pathogens of subglottic secretions and the lower respiratory tract
Time frame: through study completion, an average of 10 months
No study locations are listed for this record.
This study is status unknown, as verified in Dec 2018. You cannot join it, but the record below documents what was studied.
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The First Hospital of Jilin University