An interventional study of Computerized Cognitive Training and Control in Depressive Symptoms, sponsored by Queens College, The City University of New York. Terminated at 1 site in United States. Open to participants aged 18 Years to 29 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-09-25.
Sponsored by Queens College, The City University of New York · Not applicable, Interventional, and Other
The purpose of the study is to examine the benefits and mechanism of action of computerized cognitive training (CCT) on mood, neuropsychological deficits, everyday functioning, and brain activity among young adults with a range of depressive symptoms.
8,057 studies on the registry are indexed under Depression; 1,641 are open to participants now.
This study's enrollment of 28 is below the median of 84 across 6,720 interventional studies indexed under Depression.
Browse Depression studies →Queens College, The City University of New York is the lead sponsor of 13 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
This group will complete EF/PS (executive functioning/processing speed) computerized cognitive training (CCT) which includes games specifically focused on executive function \& processing speed.
Other: Computerized Cognitive Training
This group will complete verbal-focused computerized cognitive training.
Other: Computerized Cognitive Training
This group will not receive cognitive training during study participation.
Other: Control
Participants will complete 8 weeks of computerized cognitive training through the Peak platform on mobile devices.
This group will not receive computerized cognitive training.
Change in Sheehan Disability Scale
Self-report questionnaire of everyday functioning. It includes three subscales: work, social life, leisure activities, and home life or family responsibilities. Each subscale is rated on a 10-point scale for a minimum total score of 0 and a maximum total summed score of 30 across the three subscales. High scores are associated with more impairment.
Time frame: Screen, Week 0, Week 4, Week 8, 3-month follow-up
Change in Hamilton Depression Rating Scale
Clinician-rated measure of depression composed of 21 questions. The first 17 items are scored: eight items have a 5-point scale, nine items have a 3-point scale. Total score range is 0-52. Higher scores indicate more severe symptoms.
Time frame: Screen, Week 0, Week 4, Week 8, 3-month follow-up
Change in DKEFS Trail Making Test - Condition 4
Measure of executive function. It is a switching task that requires the subject to connect numbers and letters in an alternating pattern (1-A-2-B, etc.) as quickly as possible.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Change in Emotional Go/No Go Task (fMRI)
Measure of behavioral inhibition and set shifting. Participants must press a button for pre-specified to go trials and withhold pressing the button for pre-specified no-go trials.
Time frame: Week 0, Week 4 or Week 8 (depending on randomization)
Change in Beck Depression Inventory-II
Self-report questionnaire of depression composed of 21 questions on a 4-point scale. Total score ranges from 0-63. Higher scores indicate worse symptom severity.
Time frame: Screen, weekly for weeks 0-8, 3-month follow-up
Change in WAIS-IV Coding
Participants are required to copy symbols paired with numbers in a 120 second time limit. The score is the number correct in the allotted time.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Change in Connectivity Index (resting state fMRI)
Measure of resting state fMRI. Higher scores indicate more connectivity within the network
Time frame: Week 0, Week 4 or Week 8 (depending on randomization)
Change in DKEFS Trail Making Test - Condition 2
Measure of processing speed. This is a paper and pencil test requiring subjects to connect in order 25 encircled numbers randomly arranged using pencil lines.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Change in DKEFS Color-Word Interference Test
Measure of response inhibition. This test is divided into four sections: color naming, word reading, color-word inhibition, and color-word inhibition/ switching. The score in each condition is the completion time as well as the number of errors and self-corrections.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Change in WAIS-IV Digit Span Forwards
Measure of attention. This test requires participants to repeat back strings of digits in the same order in which they heard them.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Change in WAIS-IV Digit Span Backwards
Measure of working memory. This test requires participants to repeat back strings of digits in the reverse order in which they heard them.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Change in WAIS-IV Symbol Search
Measure of processing speed. Subjects are required to visually scan and mark off the same object as a target stimulus among a set of distractors in a 120 second time limit.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Change in DKEFS Letter and Category Naming Test
Measure of verbal fluency. This test requires subjects to generate words that begin with a particular letter or belong to a particular semantic category as quickly as possible. Total score is the number of words generated in 60 seconds per trial.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Change in California Verbal Learning Test-II
Measure of short-term and long-term verbal memory. For this test, the participant is read a list of words five times. He/she is asked to recall what was on the list immediately after each reading of the list. After a delay, the participant is again asked to recall what words were on the list.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Change in Brief Visuospatial Memory Test-Revised
Measure of visual spatial memory. Subjects reproduce a series of six designs on paper, visually presented for 10 seconds on three trials. After a delay, the subject is asked to recall the presented designs again.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Plan to share: No
This study is terminated, as verified in Sep 2022. You cannot join it, but the record below documents what was studied.
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Queens College, The City University of New York