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CompletedNCT03808571Updated Jan 22, 2019

Cord Blood Nesfatin-1 and Irisin in the Intrauterine Growth Restricted Fetuses

An observational study in Nesfatin-1, Irisin and Intrauterine Growth Restriction, sponsored by Yuzuncu Yıl University. Completed at 1 site in Turkey. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2019-01-22.

Sponsored by Yuzuncu Yıl University · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
66
Ages
18 Years to 45 Years
Sex
Female
01

Study summary

: The aim of this study is to investigate Cord blood irisin and nesfatin-1 levels in pregnancies with intrauterine growth retardation and to determine whether they are associated with abnormal fetal doppler findings or not.

Read the detailed description

This study was conducted at Yüzüncü Yıl University Medical Faculty Obstetrics and Gynecology Clinic. The study group included 34 pregnant women ranged from 18 to 45 years old who have intrauterine growth retardation and underwent ceseraen section. 32 pregnant women who had no abnormality on prenatal follow-up and underwent elective ceserean seciton served as control group. The maternal age, height, weight, body mass index (BMI), systolic and diastolic blood pressures were recorded in both groups of patients. Maternal serum total blood count and biochemical parameters were obtained from the laboratory parameters. Gestational week at birth, birth weight, sex, 1st and 5th minute APGAR scores were recorded. Blood samples were collected from all the cases during the cesarean section for measurmenet of nesfatin-1 and irisin by doubly clamped umbilical cord. Blood samples were immediately centrifuged in sterile tubes and maintained at -80 ° C until assessed.

02

Conditions studied

  • Nesfatin-1
  • Irisin
  • Intrauterine Growth Restriction
03

In context

Fetal Growth Retardation

264 studies on the registry are indexed under Fetal Growth Retardation; 66 are open to participants now.

This study's enrollment of 66 is below the median of 161 across 142 observational studies indexed under Fetal Growth Retardation.

Browse Fetal Growth Retardation studies →

Lead sponsor

Yuzuncu Yıl University is the lead sponsor of 124 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Female
Sampling method
Non-probability sample

Study population

Pregnant women

Inclusion criteria

  • Pregnant women with intrauterine grwoth rectricted fetuses.
  • Healthy pregnancies

Exclusion criteria

Exclusion Criteria:

  • Pregnant women with chronic medical conditions
  • multiple pregnancies
  • fetuses with fetal malfomations or genetic syndromes
  • pregnant women older than 45 years old
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
66 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • Study group

    Pregnancies complicated with intrauterine growth restricted fetuses

    Other: cord blood specimen during the delivery

  • Control group

    Healthy pregnancies

    Other: cord blood specimen during the delivery

Interventions

  • Othercord blood specimen during the delivery

    The cord blood will be taken during the delivery of baby.

06

What researchers measure

Primary outcomes

  1. cord blood nesfatn-1 level measurement

    cord blood levels of nesfatin-1 in pregnancies with intrauterine growth restricted fetuses and healthy pregnancies.

    Time frame: 9 months

Secondary outcomes

  1. Cord blood irisin level measurement

    ord blood levels of irisin in pregnancies with intrauterine growth restricted fetuses and healthy pregnancies.

    Time frame: 9 months

07

Study locations

1 site
  • Yuzuncu Yil University, Medical faculty, department of obstetric and gynecology
    Van, 65000, Turkey
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 22, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03808571
Lead sponsor
Yuzuncu Yıl University
Responsible party
erbil karaman (Associate doctor, Yuzuncu Yıl University) — Principal investigator
First posted
Jan 17, 2019
Start date
Jan 1, 2018
Primary completion
Jan 10, 2019
Completion
Jan 15, 2019
Last update
Jan 22, 2019

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2019. You cannot join it, but the record below documents what was studied.

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