An observational study in Cataract and Down Syndrome, sponsored by University of Colorado, Denver. Terminated at 1 site in United States. Open to participants aged 1 Month to 18 Years. Per ClinicalTrials.gov, last updated 2020-07-07.
Sponsored by University of Colorado, Denver · Observational
This study involves the collection ocular lens tissue from individuals with Down syndrome and age-matched controls at the time of cataract surgery.
Individuals with Down syndrome have an increased rate of cataract. The reason for this increase is unclear. Normally, once cataracts become a significant impairment, an ophthalmologist will determine when cataract surgery should be performed. When this surgery is performed, cataractous tissues are cut out and discarded with medical waste. In this study, these tissue will be collected and protein analysis performed to determine what changes in different proteins are found in Down syndrome lenses as compared to normal cataractous lenses.
432 studies on the registry are indexed under Down Syndrome; 100 are open to participants now.
This study's enrollment of 1 is below the median of 150 across 141 observational studies indexed under Down Syndrome.
Browse Down Syndrome studies →University of Colorado, Denver is the lead sponsor of 1,499 studies on the registry; 315 are open to participants now.
Of its 139 completed or terminated interventional studies of FDA-regulated products, 89 (64%) have results posted.
Counted across the registry records on this site, refreshed daily.
Individuals with Down syndrome having cataract surgery or age-matched control.
Exclusion Criteria:
Individuals with Down syndrome undergoing cataract surgery.
Procedure: cataract surgery
Age-matched controls undergoing cataract surgery.
Procedure: cataract surgery
tissue collection.
Change in protein composition
western blot analysis of proteins from cataractous tissue
Time frame: one week after collection of tissue
Plan to share: No — Age, trisomy status, protein concentration levels
No publications or documents are linked to this record.
This study is terminated, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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University of Colorado, Denver