An observational study in Computed Tomography, Carcinogenesis and Radiation Exposure, sponsored by Seoul National University Bundang Hospital. Status unknown at 1 site in Korea, Republic of. Per ClinicalTrials.gov, last updated 2020-02-17.
Sponsored by Seoul National University Bundang Hospital · Observational
The purpose of this study is to compare the incidence rate of leukemia between CT-exposed and CT-unexposed group in patients who underwent appendectomy in South Korea.
South Korea has a single-payer healthcare system, administered by National Health Insurance Service (NHIS). As healthcare providers in South Korea need to claim reimbursement to NHIS for the vast majority of diagnostic and therapeutic procedures, the NHIS database enabled us to construct a large cohort who did or did not undergo CT for appendicitis. The purpose of this study is to compare the incidence rate of cancer between CT-exposed and CT-unexposed group in patients who underwent appendectomy in South Korea.
412 studies on the registry are indexed under Appendicitis; 62 are open to participants now.
This study's planned enrollment of 1,000,000 is above the median of 200 across 150 observational studies indexed under Appendicitis.
Browse Appendicitis studies →Seoul National University Bundang Hospital is the lead sponsor of 368 studies on the registry; 55 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients who underwent appendectomy under the diagnosis of appendicitis
Exclusion Criteria:
Radiation: Abdomen CT
Radiation: Abdomen CT
Patients are divided into CT-exposed or unexposed group according to the presence of claims codes of abdominopelvic CT conducted within seven days before and after appendectomy. The seven-day threshold is arbitrarily determined considering the delay in the diagnosis of appendicitis and the postoperative examination for surgical complication.
Age and sex-standardized incidence rate ratio (IRR) for malignancies of hematologic system
Hematologic malignancies are categorized into lymphomas, multiple myeloma, leukemias, myelodysplasia and others using ICD-10 codes.
Time frame: Cancer occurrence after a lag period (2 years)
Age and sex-standardized incidence rate ratio (IRR) for malignancies of abdominal organs
age and sex-standardized IRRs for malignancies of abdominal organs for CT-exposed versus unexposed patients.
Time frame: Cancer occurrence after a lag period (2 years)
Age and sex-standardized incidence rate ratio (IRR) for all cancers
age and sex-standardized IRRs for all cancers for CT-exposed versus unexposed patients.
Time frame: Cancer occurrence after a lag period (2 years)
Sensitivity analysis
Various lag periods will be applied for the outcomes.
Time frame: Cancer occurrence after different lag periods (6 months, 1 year, 3 years and 5 years)
Subgroup analysis by subsequent CT scans conducted more than 7 days after appendectomy
IRR in patients who underwent CT after appendectomy IRR in patients who did not undergo CT after appendectomy
Time frame: CT undergone more than 7 days after appendectomy will be counted.
Subgroup analysis
by age and sex
Time frame: Cancer occurrence after a lag period (2 years)
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Seoul National University Bundang Hospital