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Status unknownNCT03741998Updated Jul 22, 2019

Nasopharyngeal Airway Facilitate Transnasal Humidified Rapid Insufflation Ventilatory Exchange

An interventional study of Nasopharyngeal airway in Hypoxia and Hypercapnia, sponsored by RenJi Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-07-22.

Sponsored by RenJi Hospital · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Jul 2019), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
120
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

For performing transnasal humidified rapid insufflation ventilatory exchange (THRIVE), jaw-thrust maneuver have to maintain to make sure the airway open and the CO2 clearance during apnoea. The objective of present study is to prove that nasopharyngeal airway facilitate THRIVE and no need jaw-thrust maneuver and maintain the similar PO2 and PCO2 during apnoea.

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Conditions studied

  • Hypoxia
  • Hypercapnia
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In context

Hypoxia

1,245 studies on the registry are indexed under Hypoxia; 239 are open to participants now.

This study's planned enrollment of 120 is above the median of 45 across 864 interventional studies indexed under Hypoxia.

Browse Hypoxia studies →

Lead sponsor

RenJi Hospital is the lead sponsor of 550 studies on the registry; 248 are open to participants now.

Browse RenJi Hospital studies →

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Signed informed consent.
  • Undergoing surgery with general anaesthesia.
  • Adult, >18 years old.
  • American Society of Anesthesiology classification I-II.

Exclusion criteria

Exclusion Criteria:

  • Coagulation disorders or a tendency of nose bleeding
  • An episode/exacerbation of congestive heart failure (CHF) that requires a change in medication, diet or hospitalization from any cause in the last 6 months
  • Severe aortic stenosis or mitral stenosis;
  • Cardiac surgery involving thoracotomy (e.g., coronary artery bypass graft (CABG), valve replacement surgery) in the last 6 months;
  • Acute myocardial infarction in the last 6 months;
  • Acute arrhythmia (including both tachycardia and bradycardia) with hemodynamic instability;
  • Diagnosed COPD or current other acute or chronic lung disease requiring supplemental chronic or intermittent oxygen therapy);
  • Increased intracranial pressure;
  • ASA >II;
  • Mouth, nose, or throat infection;
  • Fever, defined as core body temperature > 37.5°C;
  • Pregnancy, breastfeeding or positive pregnancy test;
  • Emergency procedure.
  • Patient with known or suspected difficult airway
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
120 participants (estimated)

Study arms

  • No intervention
    THRIVE

    Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) during induction using jaw-thrust maneuver.

  • Active comparator
    THRIVE with nasopharyngeal airway

    Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) during induction with nasopharyngeal airway.

    Device: Nasopharyngeal airway

Interventions

  • DeviceNasopharyngeal airway

    THRIVE with a regular nasopharyngeal airway.

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What researchers measure

Primary outcomes

  1. The partial pressure of carbon dioxide (pCO2)

    Time frame: From start to end of THRIVE(20 minutes)

  2. The partial pressure of oxygen(PO2)

    Time frame: From start to end of THRIVE(20 minutes)

07

Study locations

1 of 1 sites recruiting
  • Renji Hospital
    Shanghai, Shanghai Municipality 200127, China
    Recruiting
08

References and documents

Publications

  • Chen L, Yang L, Tian W, Zhang X, Zhao Y, Huang L, Tian J, Zhang J, Wu J, Yu W, Su D. Transnasal Humidified Rapid Insufflation Ventilatory Exchange With Nasopharyngeal Airway Facilitates Apneic Oxygenation: A Randomized Clinical Noninferiority Trial. Front Med (Lausanne). 2020 Nov 27;7:577891. doi: 10.3389/fmed.2020.577891. eCollection 2020. PubMed 33330535 ↗

Individual participant data

Plan to share: Undecided

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 22, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03741998
Lead sponsor
RenJi Hospital
Responsible party
Sponsor
First posted
Nov 15, 2018
Start date
Nov 7, 2018
Primary completion
Dec 30, 2019 (estimated)
Completion
Dec 30, 2019 (estimated)
Last update
Jul 22, 2019

Study contacts

Diansan Su, Dr.
Contact
diansansu@yahoo.com
+862168383702
Diansan Su, Dr.
study director · Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.

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