A Phase 4 interventional study of Saline injection and PRP injection in Osteoarthritis (OA) of the Knee, sponsored by National Taiwan University Hospital. Recruiting at 1 site in Taiwan. Open to participants aged 50 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-09-21.
Sponsored by National Taiwan University Hospital · Phase 4, Interventional, and Treatment
This study will focus on grade I to III knee osteoarthritis by randomized controlled trials which comparing the effectiveness between placebo, autologous platelet rich plasma and autologous platelet lysate injections.
The current methods for treating knee osteoarthritis include delaying the disease progression and joint replacement surgery. The usual treatment methods are mostly temporary, such as taking drug and hyaluronic acid injection. Therefore, finding the safe and effective methods will greatly reduce medical resource, medical expenses and surgery cost, etc., and restore the patient's quality of life. Platelet lysate is the product of complete activation from autologous platelet. It contains rich growth factors and cytokines such as PDGF, TGF-β, VEGF, EGF and IGF, etc. It can support cell growth and doesn't have any white blood cells in it. It is superior to the platelet rich plasma because of reducing the overall inflammatory response and pain of the patient during treatment.
4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.
This study's planned enrollment of 150 is above the median of 70 across 3,440 interventional studies indexed under Osteoarthritis.
Browse Osteoarthritis studies →National Taiwan University Hospital is the lead sponsor of 2,563 studies on the registry; 569 are open to participants now.
Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Sodium Chloride injection into the study knee joint every 4 weeks for a total of 3 injections
Other: Saline injection
PRP injection into the study knee joint every 4 weeks for a total of 3 injections
Biological: PRP injection
PL injection into the study knee joint every 4 weeks for a total of 3 injections Platelet lysate is the product of nature activation from autologous platelet.
Biological: PL injection
5ml Placebo infusion of 0.9% Sodium Chloride
Device: "Aeon" Acti-PRP 5ml autologous platelet rich plasma injection
Device: "Aeon" Acti-PRP 5ml autologous platelet lysate injection
Pain score of the patient
Using Visual Analog Score (from 0 to 10, 0 indicate no pain and 10 indicate maximal pain) to evaluate pain of surgical wound of the patient
Time frame: up to 24 weeks after surgery
Knee functional score
Using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
Time frame: up to 24 weeks after surgery
X-ray
Knee X-ray image
Time frame: up to 24 weeks after surgery
Ultrasonic image
Ultrasonic-between thickness of the medial and lateral sides of the femoral condyle
Time frame: up to 24 weeks after surgery
adverse events
adverse events in clinical trial
Time frame: up to 24 weeks after surgery
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
National Taiwan University Hospital