An interventional study of Exercise training in Obesity, Insulin Resistance and Type2 Diabetes, sponsored by University of Turku. Completed at 1 site in Finland. Open to participants aged 30 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-03-02.
Sponsored by University of Turku · Not applicable, Interventional, and Prevention
Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge. The ultimate goal of this proposal is to develop a statistical model to assess systemic cross-talk between brain, peripheral tissues, gut microbiota and glucose metabolism. Integrated with exercise training intervention the results will be utilized to provide disease risk profiling and personalized predictions of exercise training as a drug free treatment for insulin resistance and type 2 diabetes.
1,960 studies on the registry are indexed under Insulin Resistance; 306 are open to participants now.
This study's enrollment of 24 is below the median of 40 across 1,536 interventional studies indexed under Insulin Resistance.
Browse Insulin Resistance studies →University of Turku is the lead sponsor of 122 studies on the registry; 16 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Six months of exercise training
Behavioral: Exercise training
Subjects are required to exercise four times a week during six months. Exercise training consists of endurance training, resistance training and high-intensity interval training adjusted to subject's fitness level.
Effects of exercise training - brain glucose uptake
Brain glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with \[18F\]-labelled fluoro-deoxy-glucose (FDG) tracer.
Time frame: The change from baseline to 6 months
Effects of exercise training - brain inflammation
Brain inflammation (dimensionless; standistibution volume ratio) is measured with positron emission tomography (PET) with PK11195 tracer
Time frame: The change from baseline to 6 months
Effects of exercise training - liver glucose uptake
Liver glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with \[18F\]-labelled fluoro-deoxy-glucose (FDG) tracer
Time frame: The change from baseline to 6 months
Effects of exercise training - adipose tissue glucose uptake
Adipose tissue glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with \[18F\]-labelled fluoro-deoxy-glucose (FDG) tracer
Time frame: The change from baseline to 6 months
Effects of exercise training - whole-body insulin sensitivity
Whole-body insulin sensitivity (M-value; micromol/100g/min) during the hyperinsulinemic euglycemic clamp
Time frame: The change from baseline to 6 months
Effects of exercise training - ectopic fat
Ectopic fat content (%) is measured using magnetic resonance spectroscopy (MRS)
Time frame: The change from baseline to 6 months
Plan to share: Undecided — IPD of the main outcome measures will be opened if possible to such as extent that individuals cannot be identified.
This study is completed, as verified in Feb 2022. You cannot join it, but the record below documents what was studied.
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University of Turku