An observational study in Osteo Arthritis Knee, sponsored by KU Leuven. Completed at 1 site in Belgium. Open to participants aged 50 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-02-08.
Sponsored by KU Leuven · Observational
Knee osteoarthritis is an important cause of functional disabilities at old age. Previous research has demonstrated that individuals with knee osteoarthritis have reduced knee-extensor strength in comparison to healthy individuals. However, rapid power production declines more than strength as a consequence of ageing and is more predictive of functional capacity. However, limited research has investigated whether individuals with knee osteoarthritis have reduced ability to develop strength and power rapidly on top of reduced maximal strength capacities, which is the primary aim of the current study.
4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.
This study's enrollment of 48 is below the median of 100 across 791 observational studies indexed under Osteoarthritis.
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Adults between 50 and 80 years with or without knee osteoarthritis. Subjects are sedentary or recreationally active.
Group with knee osteoarthritis:
Exclusion Criteria:
Healthy group:
Group with knee osteoarthritis:
Diagnostic Test: Muscle function test
Diagnostic Test: Muscle function test
Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests
Rate of power development
Subjects perform a test protocol on a Biodex dynamometer, consisting of isotonic contractions of the leg-extensor muscles. Subjects are instructed to kick as fast as possible against different (relative) loads. The rate of power development (watt/s) is defined as the linear slope of the power-time curve and is measured from the onset of movement till peak power.
Time frame: up to 3 months
Maximal isometric strength
Maximal strength (Nm) is measured by means of unilateral isometric knee-extensor tests on a Biodex dynamometer.
Time frame: up to 3 months
Maximal isokinetic strength
Maximal strength (Nm) is measured by means of unilateral isokinetic knee-extensor tests on a Biodex dynamometer.
Time frame: up to 3 months
Stair Climbing performance
Stair ascent duration (in s), the time needed to ascent a flight of stairs.
Time frame: up to 3 months
Gait speed
The average speed to walk 10m as fast as possible (in m/s).
Time frame: up to 3 months
5 repetition sit-to-stand test
The time needed to perform 5 sit-to-stand transitions (in s).
Time frame: up to 3 months
Timed-up-and-go
The time needed to stand up from a chair, walk 3m, turn, walk back and sit down.
Time frame: up to 3 months
Handgrip strength
Handgrip strength (kg) evaluated with Jamar dynamometer.
Time frame: up to 3 months
Plan to share: No
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This study is completed, as verified in Feb 2019. You cannot join it, but the record below documents what was studied.
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