An interventional study of Advanced Platelet Rich Fibrin (A-PRF) and Leukocyte- and platelet-rich fibrin (L-PRF) in Pain, Postoperative, Trismus and Swelling, sponsored by Near East University, Turkey. Completed at 1 site in Turkey. Open to participants aged 18 Years to 26 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-09-14.
Sponsored by Near East University, Turkey · Not applicable, Interventional, and Supportive care
In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus after mandibular third molar surgery. The study included a total of 27 patients with bilateral impacted mandibular third molar which surgically operated at different times. Patients were evaluated in two randomly separated groups. For the first group; A-PRF and for the second group; L-PRF was applied into the tooth socket. The outcomes variables were; pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed on the basis of; 1st, 2nd, 3rd and 7th days following the operation.
195 studies on the registry are indexed under Tooth, Impacted; 20 are open to participants now.
This study's enrollment of 27 is below the median of 53 across 164 interventional studies indexed under Tooth, Impacted.
Browse Tooth, Impacted studies →Near East University, Turkey is the lead sponsor of 44 studies on the registry; 4 are open to participants now.
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Exclusion Criteria:
A-PRF was applied into the tooth socket after mandibular third molar surgery.
Genetic: Advanced Platelet Rich Fibrin (A-PRF)
L-PRF was applied into the tooth socket after mandibular third molar surgery.
Genetic: Leukocyte- and platelet-rich fibrin (L-PRF)
blood samples collected in 10 ml of vacuumed plain glass tubes were centrifuged for 14 minutes at 1500 rpm without anticoagulant agents in order to obtain A-PRF
blood samples collected in 10 ml of glass coated plastic tubes were centrifuged without anticoagulant agents for 10 minutes in order to obtain L-PRF
Pain Scores Evaluted
For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).
Time frame: 1st day after the operation.
Pain Scores Evaluted
For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).
Time frame: 2nd day after the operation.
Pain Scores Evaluted
For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).
Time frame: 3rd day after the operation.
Pain Scores Evaluted
For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).
Time frame: 7th day after the operation.
Number of Analgesics Taken by the Patients
Time frame: Each patient was evaluated on the 1st, 2nd, 3rd, and 7th days after the operation.
Trismus
Trismus was assessed by measuring the distance between the mesioincisal corner of the maxillary and mandibular right incisors while mouth was fully opened
Time frame: Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation.
Swelling on the cheek
In order to record swelling, a modification of the tape measurement method
Time frame: Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation.
This study is completed, as verified in Sep 2018. You cannot join it, but the record below documents what was studied.
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Near East University, Turkey