An observational study in Trigeminal Neuralgia, sponsored by Danish Headache Center. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-09-05.
Sponsored by Danish Headache Center · Observational
The most common cause of trigeminal neuralgia is considered to be a neurovascular contact. However, this etiological factor only seem to be present in half of the patient group. Thus the etiology of the other half is unknown.
Gain-of function genetic mutations in voltage gated sodium channels have been hypothesized as playing a role in the etiology of trigeminal neuralgia but it has yet to be confirmed. In recent years gain-of-function mutations have been identified as a causative factor in other pain-diseases presenting with trigeminal neuralgia phenotypic similarities.
The aim of this study was to indentify VGSC gene mutations, specifically SCN9A, SCN10A and SCN11A genes, in a group of well characterized trigeminal neuralgia patients.
Setting: The study will be conducted at The Danish Headache Center, Rigshospitalet - Glostrup, Denmark (inclusion of patients and written Informed Consent, patient interview, phenotyping/diagnosis, neurological examination, blood sample.
Departments of Neurology and Clinical Genomics of the Maastricht University Medical Center, Maastricht, the Netherlands: Targeted NG Sanger Sequencing
135 studies on the registry are indexed under Trigeminal Neuralgia; 44 are open to participants now.
This study's enrollment of 33 is below the median of 82 across 34 observational studies indexed under Trigeminal Neuralgia.
Browse Trigeminal Neuralgia studies →Danish Headache Center is the lead sponsor of 125 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients suffering from trigeminal neuralgia and has an onset of disease before the age of 42 and/or first-line relative with TN.
Subjects of both sexes with TN must meet the following inclusion criteria to be eligible for participation:
3.2. Exclusion Criteria
Subjects will be excluded if one of the following exclusion criteria is met:
No intervention is conducted as the study aim is to explore the link between pheno- and genetype of trigeminal neuralgia
Exploratory study of association between phenotype and genotype of trigeminal neuralgia
To identify genetic mutations, via Sanger Next Generation Sequencing, in either NaV 1.7, NaV1.8 or NaV1.9 encoding genes and link the findings to the phenotype of trigeminal neurlagia patients with a high genetic load.
Time frame: 1 day
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.
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Danish Headache Center