An interventional study of tonsillectomy in Tonsil Disease, Tonsillitis and Tonsillitis Acute, sponsored by Turku University Hospital. Active, not recruiting at 1 site in Finland. Open to participants aged 16 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-09-10.
Sponsored by Turku University Hospital · Not applicable, Interventional, and Treatment
Comparing the classical extracapsular tonsillectomy (TE) performed with electrosurgery to intracapsular approaches (SIPT) by coblation or microdebrider. The patient group is adults with recurrent or chronic tonsillitis
Extracapsular tonsillectomy (TE) with monopolar electrosurgery is the most commonly used approach in adult tonsil surgery in Turku University Central Hospital, Finland.
In our study setting we are comparing intracapsular tonsillectomy (subtotal/intracapsular/partial tonsillectomy (SIPT) ) as the intervention group with extracapsular tonsillectomy as the control group.
SIPT is done with either coblation or microdebrider and TE with monopolar electrosurgery.
Indications for surgery are recurrent tonsillitis or chronic tonsillitis. The patient group is adults (16-65 years)
Safety, efficiency and cost-effectiveness are monitored in a prospective, patient-blinded and randomised study setting.
103 studies on the registry are indexed under Tonsillitis; 12 are open to participants now.
This study's enrollment of 167 is above the median of 100 across 87 interventional studies indexed under Tonsillitis.
Browse Tonsillitis studies →Turku University Hospital is the lead sponsor of 287 studies on the registry; 67 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Extracapsular tonsillectomy (ECTE) with monopolar electrosurgery
Procedure: tonsillectomy
Intracapsular tonsillectomy (ICTE) with microdebrider
Procedure: tonsillectomy
Intrapsular tonsillectomy (ICTE) with coblator
Procedure: tonsillectomy
removal of tonsil tissue as described in the study arms
Also known as: tonsil removal, tonsil surgery
Post-operative recovery
Pain post-operatively after discharge as self-reported pain intensity over the past day. Each day is scored with the modified Brief Pain Inventory and recovery is achieved when pain score reaches preset values. Recovery speed defined as pain VAS-score 3 or less at rest; or pain VAS-score 5 or less without regular analgesics use. Daily questionnaire used: Brief Pain Inventory.
Time frame: 21 days
Analgesics use
Need for analgesics postoperatively during 21 days. Measured as number of naprometin tablets/ day and the number of tramadol-paracetamol combination tablets/day.
Time frame: 21 days
Post-operative bleeding
Bleeding post-operatively at the ward or at any point during 21 days. Measured as 1-4 (1= bleeding, stopped spontaneously, no contact with staff; 2: Contact with ER, bleeding stopped without intervention; 3: Bleeding, needed intervention (packing, topical adrenalin, electrosurgical hemostasis; 4: Needed OR-time, blood transfusion, ward days
Time frame: 21 days
Life Quality
Quality of life as defined by the questionnaires: Tonsillectomy Outcome Inventory 14 "TOI-14" preoperatively and 6 months after operation;
Time frame: 6 months
Residual tonsil tissue
Residual tonsil measured right after surgery is completed and at 6 months follow-up.
Time frame: 6 months
Revision surgery
The need of revision surgery after tonsillectomy, recorded with questionnaire: Nordic Tonsil Surgery Register
Time frame: 5 years
Throat problems
Throat problems as described by the Nordic Tonsil Surgery Register at different time points postoperatively
Time frame: 5 years
Life quality
Quality of life as defined by the questionnaires: Glasgow Benefit Inventory "GBI" at 6 months after operation.
Time frame: 6 months
Plan to share: Yes — All data relevant to the study are included in the article or uploaded as supplementary information.
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
Time frame: Data will become available with the publication of the article
This study is active, not recruiting, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
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