An observational study in Microcephaly, sponsored by Guangzhou Women and Children's Medical Center. Completed at 1 site in China. Open to participants aged Up to 24 Months, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-10-01.
Sponsored by Guangzhou Women and Children's Medical Center · Observational
Screening for microcephaly is important at birth and during early childhood. The Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM) aims to establish a multicentric surveillance system for microcephaly in newborns and infants, to develop a new head circumference reference and microcephaly criteria basing on the local population in Guangzhou, to improve the prediction model of microcephaly, and to follow up the outcomes of the children diagnosed with microcephaly.
Microcephaly is associated with neurological dysfunctions in infants and children. There is not a uniform diagnostic criteria for microcephaly. The World Health Organization (WHO) recommended a criteria of head circumference (HC) less than 2 standard deviations (SD) below the mean of the Intergrowth-21 standard, which was found not applicable to the newborns and infants in Guangzhou.In the GSCSM, the HC measures of newborns are conducted by trained midwives using a standard tool, and extensive information including adverse perinatal outcomes are collected. Longitudinal follow up of infants' neurodevelopment in cognitive, motor, emotional and other domains are also to be conducted. The GSCSM intends to find out the infants who are 'real microcephaly' and most at risk of short-term or long-term adverse outcomes in Guangzhou.
22 studies on the registry are indexed under Microcephaly; 5 are open to participants now.
This study's enrollment of 47,369 is above the median of 232 across 16 observational studies indexed under Microcephaly.
Browse Microcephaly studies →Guangzhou Women and Children's Medical Center is the lead sponsor of 58 studies on the registry; 30 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study population are infants born in the maternity hospitals from Guangzhou surveillance system.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Prevalence of microcephaly
Assessed by the head circumference measured using a standard tool
Time frame: At birth
Neurodevelopmental performance of children
Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules or Ages and Stages Questionnaire
Time frame: At birth, 6 weeks, 6 months, 1 year and 2 years
Head circumference changes of children
Head circumference changes from birth to infancy (catch-up or drop)
Time frame: At birth, 6 weeks, 6 months, 1 year to 2 years
Plan to share: Undecided
Ran from Feb 2017 to primary completion in Sep 2024, 91 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Sep 2024. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Guangzhou Women and Children's Medical Center