An interventional study of Lifestyle modification in Pregnancy Outcomes, Child Development and Pregnancy Complications, sponsored by Guangzhou Women and Children's Medical Center. Recruiting at 2 sites in China. Open to female participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-16.
Sponsored by Guangzhou Women and Children's Medical Center · Not applicable, Interventional, and Prevention
The main objective of this study is to test the efficacy of an intervention package (dietary, physical and lifestyle modification) during pregnancy in improving the clinical outcomes of mother-infant dyads.
411 studies on the registry are indexed under Pregnancy Complications; 113 are open to participants now.
This study's planned enrollment of 1,160 is above the median of 144 across 205 interventional studies indexed under Pregnancy Complications.
Browse Pregnancy Complications studies →Guangzhou Women and Children's Medical Center is the lead sponsor of 58 studies on the registry; 30 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
A combination of dietary, physical activity and lifestyle modification.
Behavioral: Lifestyle modification
No additional intervention beyond standard care procedure.
This lifestyle modification aiming to provide proactive health management during pregnancy, which contains the following: 1) balanced dietary intake based on the Chinese Dietary Guideline; 2) sufficient physical activity; 3) changes in lifestyles (e.g. sleep, sun exposure etc.)
Maternal gestational weight change
Maternal weight prior to pregnancy (or within 8 weeks of pregnancy), at around 20, 26, 32 weeks' gestation, before delivery and one month postpartum will be determined by digital scales, changes in maternal weight during pregnancy will be recorded in kg.
Time frame: From pregnancy until one month postpartum
Newborn size
Weight (kg) will be measured with digital scales and height/length (cm) will be measured in supine with tape, comparing against reference to derived gestational age and sex-specific growth parameter Z-scores. To identify whether the neonates was small/appropriate/large for gestational age.
Time frame: Day 1 after birth
Neonatal skinfold thickness (at birth)
Measured with skinfold caliper, a summation of skinfold thickness at several body sites including triceps, biceps, subscapular, suprailiac and thigh, will be derived in cm.
Time frame: Day 1 after birth
Maternal blood lipid profile postpartum (3 years)
Measured by autoanalyzer, total lipids (total cholesterol, triglycerides, high/low density protein cholesterol) expressed in mmol/L.
Time frame: Three years after delivery
Maternal blood glucose profile postpartum (3 years)
Measured by autoanalyzer, blood glucose level in mmol/L.
Time frame: Three years after delivery
Maternal blood insulin profile postpartum (3 years)
Measured by commercial ELIZA kit, total and free insulin in pmol/L.
Time frame: Three years after delivery
Child blood lipid profile (3 years)
Measured by autoanalyzer, total lipids (total cholesterol, triglycerides, high/low density protein cholesterol) expressed in mmol/L.
Time frame: At three years of age
Child blood glucose profile (3 years)
Measured by autoanalyzer, blood glucose level in mmol/L.
Time frame: At three years of age
Child blood insulin profile (3 years)
Measured by commercial ELIZA kit, total and free insulin in pmol/L.
Time frame: At three years of age
Child growth parameters (3 years)
Weight measured with digital scales in kg, length measured in standing position in cm, using weight and length to derived body mass index, comparing against age and sex-specific references for Z-score.
Time frame: At three years of age
Incidence of pregnancy complications
Incidence of physician-diagnosed pregnancy complications, including gestational diabetes mellitus, hypertensive disorders
Time frame: From 20 weeks' gestation until one month postpartum
Child skinfold thickness (6 months)
Measured with skinfold caliper, a summation of skinfold thickness at several body sites including triceps, biceps, subscapular, suprailiac and thigh, will be derived in cm.
Time frame: At six months of age
Child skinfold thickness (1 year)
Measured with skinfold caliper, a summation of skinfold thickness at several body sites including triceps, biceps, subscapular, suprailiac and thigh, will be derived in cm.
Time frame: At one year of age
Child skinfold thickness (3 years)
Measured with skinfold caliper, a summation of skinfold thickness at several body sites including triceps, biceps, subscapular, suprailiac and thigh, will be derived in cm.
Time frame: At three years of age
Child skinfold thickness (6 years)
Measured with skinfold caliper, a summation of skinfold thickness at several body sites including triceps, biceps, subscapular, suprailiac and thigh, will be derived in cm.
Time frame: At six years of age
Child growth parameters (6 months)
Weight measured with digital scales in kg, length measured with tape in supine position in cm, using weight and length to derived body mass index, comparing against age and sex-specific references for Z-score.
Time frame: At six months of age
Child growth parameters (1 year)
Weight measured with digital scales in kg, length measured with tape in supine position in cm, using weight and length to derived body mass index, comparing against age and sex-specific references for Z-score.
Time frame: At one year of age
Child growth parameters (6 years)
Weight measured with digital scales in kg, length measured in standing position in cm, using weight and length to derived body mass index, comparing against age and sex-specific references for Z-score.
Time frame: At six years of age
Child blood lipid profile (6 years)
Measured by autoanalyzer, total lipids (total cholesterol, triglycerides, high/low density protein cholesterol) expressed in mmol/L
Time frame: At six years of age
Child blood sugar profile (6 years)
Measured by autoanalyzer, blood glucose level in mmol/L.
Time frame: At six years of age
Child blood insulin profile (6 years)
Measured by commercial ELIZA kit, total and free insulin in pmol/L.
Time frame: At six years of age
Neurological development of child (1 year)
Assessed by using Gesell testing, which measures the child's cognitive, language, motor (gross \& fine) and social-emotional responses. Higher score in each domain is desired, there is no upper limit. Overall score of less than 86 indicates suspected developmental retardation.
Time frame: At one year of age
Neurological development of child (3 years)
Assessed by Ages \& Stages Questionnaires, including adaptive, motor (gross \& fine), language, and social function domains, overall score being less than -2SD of age specific mean indicates suspected developmental retardation.
Time frame: At three years of age
Maternal hand grip strength during pregnancy
Measured by high precision digital hand dynamometer, in kg
Time frame: Between 32-34 weeks' gestation
Maternal hand grip strength after delivery
Measured by high precision digital hand dynamometer, in kg
Time frame: At one month postpartum
Maternal body composition postpartum
Measured by dual-energy X-ray absorptiometry by trained physician, fat mass (kg), fat free mass (kg), and relative proportion (%) and distribution of fat mass will be described.
Time frame: At one month postpartum
Maternal blood lipid profile postpartum (6 years)
Measured by autoanalyzer, total lipids (total cholesterol, triglycerides, high/low density protein cholesterol) expressed in mmol/L.
Time frame: Six years after delivery
Maternal blood sugar profile postpartum (6 years)
Measured by autoanalyzer, blood glucose level in mmol/L.
Time frame: Six years after delivery
Maternal blood insulin profile postpartum (6 years)
Measured by commercial ELIZA kit, total and free insulin in pmol/L.
Time frame: Six years after delivery
Plan to share: No
Started Jul 2024 (actual). Primary completion is estimated for Sep 2030, 74 months after the start.
Of 119 non-industry interventional studies with no phase under Pregnancy Complications, half reached primary completion within 26 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 48. This study's planned 74 months is above that.
Counting every sponsor, half of 119 studies reached it within 26 months; a quarter within 12 and three quarters within 48.
How these figures are worked out, and which studies are left out of them.
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Guangzhou Women and Children's Medical Center