Microcephaly clinical trials
The registry lists 22 studies for Microcephaly across more than 10 countries. 5 are recruiting or about to start. 9 of them are mainly about Microcephaly (how this is decided). Per ClinicalTrials.gov, last updated 2026-09-30. Counting its narrower condition Microcephaly, Primary Autosomal Recessive, 6 too: 58 studies, 12 open.
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Who runs them
Virginia Polytechnic Institute and State University (2) · Institut National de la Santé Et de la Recherche Médicale, France (2) · University of California, San Diego (1) · University of Sao Paulo (1) · Guangzhou Women and Children's Medical Center (1) · Harvard University Faculty of Medicine (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · University of North Carolina, Chapel Hill (1)
Who these studies take
Of the 5 Microcephaly studies recruiting now, 2 (40%) set no upper age limit and 2 (40%) stop at 75 or younger. 5 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (100%) | 5 (100%) |
| 18 | 4 (80%) | 4 (80%) |
| 30 | 3 (60%) | 3 (60%) |
| 40 | 3 (60%) | 3 (60%) |
| 50 | 3 (60%) | 3 (60%) |
| 65 | 3 (60%) | 3 (60%) |
| 75 | 3 (60%) | 3 (60%) |
| 85 | 3 (60%) | 3 (60%) |
Across all 22 studies, recruiting or not: 59% stop at 75 or younger and 59% at 65; 91% take children; 14% are for women only and 0% for men only; 23% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 22 of 22. search them.
- Melpida: Recombinant Adeno-associated Virus (Serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)RecruitingNCT05518188Phase 1/21 country
- MEHMO Natural History and BiomarkersRecruitingNCT060191821 country
- The FBRI VTC Neuromotor Research ClinicRecruitingNCT033259461 country
- Register for Patients With Thyroid Hormone Resistance.RecruitingNCT065660661 country
- Human Epilepsy Genetics--Neuronal Migration Disorders StudyRecruitingNCT000416001 country
- Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of AmericaCompletedNCT028102104 countries
- Zika Virus Infection's Pregnancy Consequences in French Department of AmericaCompletedNCT029167323 countries
- North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2CompletedNCT03548779Not applicable1 country
- Summary of Infants Weighing 500 Grams or LessCompletedNCT053229801 country
- Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM)CompletedNCT036516871 country
- Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in UteroCompletedNCT029433041 country
- Intensive Therapy for Children With Microcephaly, Hyperkinetic Movements, or Global Developmental DelayCompletedNCT04816175Not applicable1 country
- Postnatal HCMV Infection in Very Preterm Infants. Implications, Morbidity, Growth and Neurodevelopmental Outcomes.WithdrawnNCT011514621 country
- Surveillance of Zika-related Microcephaly in Sub-Saharan Africa and AsiaTerminatedNCT039225945 countries
- Efficacy of Aquatic Physiotherapy in Children With Microcephaly by Zika Virus Congenital SyndromeCompletedNCT03330600Not applicable1 country
- Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus InfectionCompletedNCT036797281 country
- Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF)Status unknownNCT032553691 country
- Microcephaly Genetic Deficiency in Neural ProgenitorsCompletedNCT015650051 country
- Zika and Microcephaly: Case-control StudyCompletedNCT027418821 country
- Fetal and Maternal Head Circumference During Pregnancy in Israeli PopulationCompletedNCT025101701 country
- Dietary Supplements for the Treatment of Angelman SyndromeCompletedNCT00348933Not applicable1 country
- Evaluation of Patients With Unresolved Chromosome AbnormalitiesCompletedNCT000016391 country