An interventional study of Auditory and Gestures in Parkinson Disease and Ataxia, sponsored by Herbert H. Lehman College, City University of New York. Terminated at 1 site in United States. Open to participants aged 21 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-02-26.
Sponsored by Herbert H. Lehman College, City University of New York · Not applicable, Interventional, and Treatment
Among 1,649 studies in Parkinson Disease with a site in United States — 304 open to participants now, 387 under way, 7 of them phase 3. Parkinson Disease · United States.
Among the 1,649 studies in Parkinson Disease with a site in United States, this one is the 1,152nd largest by enrollment of the 1,256 interventional ones, is one of 90 that started in 2018, is one of 585 with no phase, and was the 890th registered.
4,573 studies on the registry are indexed under Parkinson Disease; 1,086 are open to participants now.
This study's enrollment of 6 is below the median of 40 across 3,353 interventional studies indexed under Parkinson Disease.
Browse Parkinson Disease studies →304 of the 1,649 studies in Parkinson Disease with a site in United States are open now, in 12 countries. Each count lists the studies.
Of the 748 Parkinson Disease studies recruiting now, 311 (42%) set no upper age limit and 127 (17%) stop at 75 or younger; 63 take children under 18; 189 take healthy volunteers.
This study: 21 Years and older · all sexes · healthy volunteers too.
The full table on the hub →1,649 studies; the count open now beside each. This study's row is marked.
First in 1991; this study’s year is marked. 90 started in 2018.
Median enrollment 36 across the 1,256 interventional studies, 78 across the 379 observational. Of the 1,139 that completed or were terminated, 435 (38%) have results posted.
470 of 1,649 have an industry lead sponsor. The 10 most frequent:
This is the only study on the registry with Herbert H. Lehman College, City University of New York as lead sponsor.
Herbert H. Lehman College, City University of New York has 1 study filed under Parkinson Disease — fewer than ten, so there is no comparison to draw.
142 of the studies in Parkinson Disease with a site in United States that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06976268Phase 3Biohaven Therapeutics Ltd.A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease | 2027-08 |
| NCT06098612Massachusetts General HospitalPET Imaging Evaluation of [11C]SY08 | 2026-11 |
| NCT06489483University of Texas Southwestern Medical CenterAction Regulation Behavioral | 2026-11 |
| NCT05504902Stanford UniversityVibrotactile Coordinated Reset for the Treatment of Advanced Parkinson's Disease | 2026-11-01 |
| NCT06147999First Institute of All MedicinesImpact of a Biophoton Therapy on Patients With Brain Disorders | 2026-11-08 |
Among the 1,649 studies in Parkinson Disease with a site in United States, from their registry updates:
The objectives of this study are to determine i) the effect of rhythmic entrainment of speech with hand gestures and auditory rhythmic cues on intelligibility and speech naturalness in Spanish-accented speakers of English in two pathology groups: ataxic dysarthria and hypokinetic dysarthria secondary to idiopathic Parkinson's disease; and ii) the extent to which speech rate and effort are control parameters of entrainment. These objectives will be achieved with the following specific aims:
Specific Aim 1: Determine the effect of three rates of hand gestures and auditory rhythmic cues and the degree to which learning and carry-over occur.
Specific Aim 2: Determine the effect of increased speech effort, operationalized as clear speech, and the interaction effect of clear speech with hand gestures and auditory rhythmic cues.
Specific Aim 3: Investigate the perception of speech rhythm and its relationship to entrainment.
The objectives of this study are to determine i) the effect of rhythmic entrainment of speech with hand gestures and auditory rhythmic cues on intelligibility and speech naturalness in Spanish-accented speakers of English in two pathology groups: ataxic dysarthria and hypokinetic dysarthria secondary to idiopathic Parkinson's disease; and ii) the extent to which speech rate and effort are control parameters of entrainment. These objectives will be achieved with the following specific aims:
Specific Aim 1: Determine the effect of three rates of hand gestures and auditory rhythmic cues and the degree to which learning and carry-over occur.
Specific Aim 2: Determine the effect of increased speech effort, operationalized as clear speech, and the interaction effect of clear speech with hand gestures and auditory rhythmic cues.
Specific Aim 3: Investigate the perception of speech rhythm and its relationship to entrainment.
The protocol calls for 12 talkers to participate in a single case experimental design: 6 Spanish-accented speakers of English and 6 native English speakers, and each language group consisting of 2 healthy controls, 2 adults diagnosed with ataxic dysarthria and 2 adults diagnosed with hypokinetic dysarthria secondary to idiopathic Parkinson's disease. Sixty monolingual healthy adult listeners will rate intelligibility, accentedness, and ease of understanding.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Use of hand gestures to improve speech rhythm and speech production
Behavioral: Gestures
Use of auditory cues to improve speech rhythm and speech production
Behavioral: Auditory
Use of auditory cues to improve speech production
Use of gestures to improve speech production
Intelligibility
Intelligibility = the accuracy with which a listener understands a speaker. It will be measured by having the subjects undergoing the therapy ("the talkers") read 28 phrases using accompanying gesture or auditory cues and listeners will transcribe the sentences. The number of words accurately transcribed / the number of words in the phrase = intelligibility score for each phrase per listener
Time frame: immediately upon completion of the therapy
Ease of understanding
Ease of understanding = the ease with which listeners understand the speakers. It will be measured by having the subjects undergoing the therapy ("the talkers") read 28 phrases using accompanying gesture or auditory cues and listeners will rate how easy it is to understand the talkers using a 0 to 9 visual analog scale with 0 = very easy and 9= very hard, for each phrase per listener
Time frame: Immediately upon completion of the therapy
Speech naturalness
Speech naturalness = the degree to which the listeners consider the speakers to have natural or unnatural speech. It will be measured by having the subjects undergoing the therapy ("the talkers") read 28 phrases using accompanying gesture or auditory cues and listeners will rate how natural-sounding the talker sounds by using a 0 to 9 visual analog scale with 0 = very natural and 9 = very unnatural, for each phrase per listener
Time frame: immediately upon completion of the therapy
Plan to share: Yes — De-identified data will be shared with other researchers
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report
Time frame: After completion of the study and publication of the data
Access criteria: Researchers who have contacted me directly with clear purpose and plan for use of data and then have IRB approval.
No publications or documents are linked to this record.
Ran from Sep 2018 to primary completion in Feb 2019, 5 months.
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This study is terminated, as verified in Feb 2019. You cannot join it, but the record below documents what was studied.
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