An interventional study of head-down position treatment and Conventional Rehabilitation in Ischemic Stroke, sponsored by General Hospital of Shenyang Military Region. Terminated at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-11-15.
Sponsored by General Hospital of Shenyang Military Region · Not applicable, Interventional, and Treatment
The study is designed to explore the efficacy and safety of head-down position in patients with acute ischemic stroke。
Currently, the guideline recommended re-perfusion such as intravenous thrombolysis and mechanical thrombectomy as the most effective treatment for acute ischemic stroke. However, the two methods are restricted by a strict time window, which greatly limits the number of the patients receiving treatment. The abundant studies have suggested that good collateral circulation can provide compensatory blood supply to save the ischemic penumbra and reduces the infarct volume, which improves the prognosis. How to improve collateral circulation in an efficient and safe way is a clinical challenge. Our recent experiment results of the animal and clinical experiments show that head-down position can significantly increase cerebral perfusion and improve neurological function. Clinically, head-down position is simple and easy to operate, and theoretically may increases brain perfusion and improve collateral circulation. A pilot randomized clinical trial is designed to investigate the effect of head-down position combined with routine rehabilitation in patients with ischemic stroke.
7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.
This study's enrollment of 12 is below the median of 50 across 5,369 interventional studies indexed under Stroke.
Browse Stroke studies →General Hospital of Shenyang Military Region is the lead sponsor of 78 studies on the registry; 33 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
head-down position treatment combined with conventional rehabilitation.
Other: head-down position treatment · Other: Conventional Rehabilitation
Conventional rehabilitation treatment
Other: Conventional Rehabilitation
In the head-down position, the body is in the supine position with the head lowered to 30 degrees
The body is in the supine position without lowered head
proportion of patients with modified Rankin Score 0 to 2
Time frame: 90 days
proportion of patients with modified Rankin Score 0 to 1
Time frame: 90 days
The percentage of reduction in Fugl-Meyer score
Time frame: 90 days
occurrence of stroke
stroke or TIA
Time frame: 90 days
The percentage of reduction in MMSE
MMSE，Mini-mental State Examination
Time frame: 90 days
The percentage of reduction in MoCA
MoCA, Montreal Congnitive Assessment
Time frame: 90 days
Incidence of major vascular events
ischemic stroke, hemorrhagic stroke, TIA, myocardial infarction, vascular death
Time frame: 90 days
the biggest tolerance time of head-down
Time frame: 90 days
This study is terminated, as verified in Nov 2021. You cannot join it, but the record below documents what was studied.
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General Hospital of Shenyang Military Region