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CompletedNCT03595631Updated Oct 22, 2018

Neurodynamic Interventions for Multiple Sclerosis

An interventional study of Physical Therapy and Physical Therapy plus Neurodynamic in Multiple Sclerosis, sponsored by Universidad Rey Juan Carlos. Completed at 1 site in Spain. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2018-10-22.

Sponsored by Universidad Rey Juan Carlos · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
32
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
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Study summary

A randomized, parallel-group, clinical trial will be conducted to compare the immediate effects of the inclusion of a neurodynamic intervention into a multimodal physiotherapy program on pressure pain sensitivity, pain and manual dexterity in patients with multiple sclerosis

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Conditions studied

  • Multiple Sclerosis

Keywords

  • neurodynamics
  • pain
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In context

Multiple Sclerosis

3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.

This study's enrollment of 32 is below the median of 50 across 2,342 interventional studies indexed under Multiple Sclerosis.

Browse Multiple Sclerosis studies →

Lead sponsor

Universidad Rey Juan Carlos is the lead sponsor of 111 studies on the registry; 22 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • a diagnosis of multiple sclerosis according to the modified McDonald criteria;
  • symptoms of paresthesia and lack of sensitivity in the upper extremity;
  • Expanded Disability Status Scale (EDSS) between 0 and 6.5 points;
  • absence of cognitive deficit.

Exclusion criteria

Exclusion Criteria:

  • any exacerbation of multiple sclerosis during the previous 3 months;
  • previous hand surgery or steroid injections treatment in the upper extremity;
  • multiple diagnoses on the upper extremity (e.g., cervical radiculopathy);
  • cervical, shoulder, or upper extremity trauma;
  • other comorbid musculoskeletal medical conditions;
  • mini-mental state examination \<25
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
32 participants (actual)

Study arms

  • Active comparator
    Physical Therapy

    Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week.

    Other: Physical Therapy

  • Experimental
    Physical Therapy plus neurodynamic

    Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week. In addition, they will also receive bilateral nerve slider neurodynamic interventions targeting the median, ulnar and radial nerves.

    Other: Physical Therapy plus Neurodynamic

Interventions

  • OtherPhysical Therapy

    Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week.

  • OtherPhysical Therapy plus Neurodynamic

    Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week. In addition, they will also receive bilateral nerve slider neurodynamic interventions targeting the median, ulnar and radial nerves.

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What researchers measure

Primary outcomes

  1. Changes in pressure pain sensitivity

    Pressure pain threshold over the median, ulnar and radial nerves, second metacarpal and tibialis anterior

    Time frame: Baseline and one week after the last treatment session

Secondary outcomes

  1. Changes in upper extremity pain intensity before and after the intervention

    A Numerical Pain Rate Scale (NPRS, 0-10) will be used to record the mean and the worst intensity of pain in te upper extremity

    Time frame: Baseline and one week after the last treatment session

  2. Changes in light touch detection threshold

    Light touch detection threshold will be assessed with a standardized set of modified twenty von Frey hairs

    Time frame: Baseline and after treatmentBaseline and one week after the last treatment session

  3. Changes in manual dexterity

    Bilateral manual dexterity was bilaterally assessed using the nine-hole peg test

    Time frame: Baseline and one week after the last treatment session

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Study locations

1 site
  • César Fernández-de-las-Peñas
    Alcorcon, Madrid 28922, Spain
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References and documents

Publications

  • de Dios Perez-Bruzon J, Fernandez-de-Las-Penas C, Cleland JA, Plaza-Manzano G, Ortega-Santiago R. Effects of neurodynamic interventions on pain sensitivity and function in patients with multiple sclerosis: a randomized clinical trial. Physiotherapy. 2022 Jun;115:36-45. doi: 10.1016/j.physio.2021.04.004. Epub 2021 Apr 22. PubMed 35101724 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 22, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03595631
Lead sponsor
Universidad Rey Juan Carlos
Responsible party
César Fernández-de-las-Peñas (Director of Department, Universidad Rey Juan Carlos) — Principal investigator
First posted
Jul 23, 2018
Start date
Jul 26, 2018
Primary completion
Sep 15, 2018
Completion
Oct 4, 2018
Last update
Oct 22, 2018

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Oct 2018. You cannot join it, but the record below documents what was studied.

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