An observational study in Epilepsy Generalized Idiopathic Not Intractable, sponsored by University of Alexandria. Completed. Open to participants aged 9 Years to 29 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-07-16.
Sponsored by University of Alexandria · Observational
The study aimed to study the correlation between periodic limb movement occurring during sleep and the different parameters of genetic generalized epilepsy
Although periodic limb movements are prevalent among patients with epilepsy, the exact relationship between these movements and epilepsy remains elusive. Objective: The aim of this work was to study the periodic limb movements among patients with genetic generalized epilepsy in relation to different clinical characteristics and seizure recurrence. Methods: Sixty individuals participated in this study: thirty of them were newly diagnosed with genetic generalized epilepsy and thirty were healthy individuals. Sleep quality was assessed using the Pittsburgh Sleep Quality Index questionnaire, and a standard polysomnographic study was conducted to all subjects. All patients then received sodium valproate in therapeutic doses and were followed up for six months. Electroencephalogram (EEG) was done after the follow-up period and seizure recurrence was assessed. Accordingly, patients were classified into three groups according to clinical seizure recurrence and follow-up EEG findings.
Periodic limb movement index and frequency were compared among the patients' groups and were correlated with different clinical characteristics.
39 studies on the registry are indexed under Epilepsy, Generalized; 4 are open to participants now.
This study's enrollment of 60 is below the median of 80 across 13 observational studies indexed under Epilepsy, Generalized.
Browse Epilepsy, Generalized studies →University of Alexandria is the lead sponsor of 59 studies on the registry; 5 are open to participants now.
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Thirty patients and thirty volunteer healthy controls were recruited. Patients were newly diagnosed with genetic generalized epilepsy according to the ILAE 2010 criteria who did not previously receive AEDs. The clinical seizures were either eye-witnessed by physicians or video-recorded to ensure they were true epileptic seizures. Age of participants ranged from 9 to 29 years. All patients recruited in this study had at least two unprovoked seizures occurring >24 hours apart. Patients with pre-existing psychiatric illnesses those with seizures due to toxic or metabolic causes ), infections, or structural causes, and those using hypnotic drugs were excluded. The control subjects were healthy volunteers who were not related to the patients and had no family history of epilepsy.
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Exclusion Criteria:
Group I (n=10) included patients who did not develop any major or minor seizure during the follow-up period and their follow up EEG was free of any epileptiform discharge
Group II (n=11) included patients who developed only minor seizures and their follow up EEG showed epileptiform discharge
Group III (n=9) were patients who developed one or more major seizures during the follow-up period whatever their EEG findings.
healthy volunteers (n=30) who were not related to the patients and had no family history of epilepsy.
Seizure recurrence
Clinical major or minor seizure, and electrical seizure
Time frame: 6 months
No study locations are listed for this record.
Plan to share: Undecided
Ran from Sep 2015 to primary completion in Sep 2016, 12 months.
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This study is completed, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.
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University of Alexandria