An observational study in Taste, Altered, sponsored by University of Missouri-Columbia. Completed at 2 sites in United States. Open to female participants aged 21 Years to 70 Years. Per ClinicalTrials.gov, last updated 2020-11-02.
Sponsored by University of Missouri-Columbia · Observational
It is commonly believed that a link exists between BMI and taste perception. One group of researchers observed that women who are obese experience reduced taste sensitivity when compared to normal-weight controls. Others have compared taste sensitivity between lean and obese subjects and found no significant differences. The inconsistencies in these studies demonstrate how much variation in taste sensitivity is possible when different factors are applied in research. Throughout several studies, one element remains constant - bariatric surgery causes appetite aversions. These changes in appetite and food preference likely have a large influence on the overall magnitude of post-surgical weight loss. Although many studies have investigated the changes in taste preference after bariatric surgery, few, if any, have focused on changes in sweet taste perception.
The overall goal of the present project is to determine how future bariatric surgery will affect the taste for sweet liquids. Taste perception will be assessed before surgery (pre-operative, pre-op) and after bariatric surgery, at approximately 1 month. Taste studies will be conducted with solutions prepared freshly before each test using sucrose dissolved in distilled water. Six concentrations of sucrose (table sugar) will be tasted in random order, with the most concentrated solution being roughly the sweetness of soda. The subject is blinded to the concentrations. It is hypothesized that there will be no significant difference in taste perception when pre-op and post-op values are compared. However, the investigators hypothesize that taste preference will identify solutions with lower concentrations post-op.
52 studies on the registry are indexed under Dysgeusia; 12 are open to participants now.
This study's enrollment of 21 is below the median of 104 across 22 observational studies indexed under Dysgeusia.
Browse Dysgeusia studies →University of Missouri-Columbia is the lead sponsor of 365 studies on the registry; 69 are open to participants now.
Of its 43 completed or terminated interventional studies of FDA-regulated products, 29 (67%) have results posted.
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Women aged 21-70 will be recruited from the University of Missouri Bariatric Surgery Clinic.
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Exclusion Criteria:
All subjects will be patients scheduled for bariatric surgery. There is only one arm in this study.
Other: taste test
All subjects will complete a procedure to determine their taste sensitivity to sweet tastants.
Taste Perception on an Interval Scale
Taste perception will be assessed by the subjects' responses to varying sucrose solutions. The interval scale begins with "barely detectable" at zero and goes up to "strongest imaginable" at 10. Subjects will be asked to draw an "X" at the location on the graph corresponding to their perception.
Time frame: Change from baseline to one month after bariatric surgery
Plan to share: No
This study is completed, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.
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