An interventional study of Angulus in Ventilator Adverse Event, Ventilator Associated Pneumonia and Hospital Acquired Condition, sponsored by Angulus, LLC. Completed at 1 site in United States. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2024-03-06.
Sponsored by Angulus, LLC · Not applicable, Interventional, and Prevention
Among 62 studies in Pneumonia, Ventilator-Associated with a site in United States — 4 open to participants now, 5 under way, none of them phase 3. Pneumonia, Ventilator-Associated · United States.
Among the 62 studies in Pneumonia, Ventilator-Associated with a site in United States, this one is the 31st largest by enrollment of the 49 interventional ones that give a count, is one of 2 that started in 2018, is one of 20 with no phase, and was the 49th registered.
420 studies on the registry are indexed under Pneumonia, Ventilator-Associated; 85 are open to participants now.
Browse Pneumonia, Ventilator-Associated studies →4 of the 62 studies in Pneumonia, Ventilator-Associated with a site in United States are open now. Recruiting first, the newest first:
Northwell Health · Sites in United States
Ages 0–18
University of Florida · Sites in United States
Ages 1 hrs–3 days
William Janssen, MD · Sites in United States
Ages 18–99
Johns Hopkins University · Sites in United States
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 48 Pneumonia, Ventilator-Associated studies recruiting now, 37 (77%) set no upper age limit and 6 (13%) stop at 75 or younger; 6 take children under 18; 4 take healthy volunteers.
This study: 18 Years to 75 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
62 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 2 · Phase 2 12 · Phase 3 10 · Phase 4 7
First in 2001; this study’s year is marked. 2 started in 2018.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 90 is below the median of 115 across 276 interventional studies indexed under Pneumonia, Ventilator-Associated.
Median enrollment 149 across the 49 interventional studies, 70 across the 13 observational. Of the 54 that completed or were terminated, 26 (48%) have results posted.
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15 of 62 have an industry lead sponsor. The 10 most frequent:
This is the only study on the registry with Angulus, LLC as lead sponsor.
Angulus, LLC has 1 study filed under Pneumonia, Ventilator-Associated — fewer than ten, so there is no comparison to draw.
2 of the studies in Pneumonia, Ventilator-Associated with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT04987840Johns Hopkins UniversityA Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children | 2026-12-01 |
| NCT05767671William Janssen, MDMacrophage Programing in Acute Lung Injury: MiniBAL | 2027-09-18 |
Among the 62 studies in Pneumonia, Ventilator-Associated with a site in United States, from their registry updates:
Nothing recorded among them since 2026-09-25.
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Ventilator-associated events (VAE) are a scourge of critical care settings and hospital systems at large. There is extensive evidence that ventilator-associated pneumonia (VAP) and related VAEs increase mortality rates in critically ill patients by up to 50%, while simultaneously increasing cost of care. C
Best-practice guidelines state that positioning ventilated patients at an angle between 30-45 degrees significantly reduces the potential for VAP and other VAE to develop. While the intent of the guidelines is to govern patient elevation angle, the lack of a mechanism to accurately measure patient elevation requires that nurses rely on the head-of-bed (HOB) protractor - a tool which reflects the angle of the bed, not the patient - to measure compliance. Depending upon the position and posture of the patient in the bed, a patient's elevation angle may be significantly different from the HOB angle. Critical care teams currently rely on built-in HOB protractors and digital inclinometers that measure the angle of the bed not the patient.
Angulus, LLC has developed a dual-component Angulus sensor to fill this gap in critical care technology. Angulus enables critical care practitioners to instantaneously understand a patient's elevation, identify when the patient is outside of the desired 30-45 degree recumbency scope, and efficiently correct the patient's orientation with immediate feedback. Angulus supports real-time minute-to-minute data display as well as longitudinal aggregation of data.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients with any major chest wall abnormalities, or defects, including but not limited to:
The ICU with feedback will be equipped with display device corresponding to each Angulus device with an interactive software interface which displays the patient's elevation.
Device: Angulus
The Angulus device will be on the patient but will NOT have the corresponding display data on patient elevation available to nurses.
Device: Angulus
Feedback on patient recumbency
Compliance to Head of Bed Elevation to 30 Degree or More.
Measured as a continuous variable between 0% and 100% compliance.
Time frame: 3 months
| Milestone | ICU A Feedback First, Then no Feedback, and Feedback Last | ICU B No Feedback First, Then Feedback, and No Feedback Last | ICU C: Feedback First, Then No Feedback, and Feedback Last |
|---|---|---|---|
| Started | 15 | 4 | 10 |
| Completed | 15 | 4 | 10 |
| Not completed | 0 | 0 | 0 |
| Milestone | ICU A Feedback First, Then no Feedback, and Feedback Last | ICU B No Feedback First, Then Feedback, and No Feedback Last | ICU C: Feedback First, Then No Feedback, and Feedback Last |
|---|---|---|---|
| Started | 17 | 9 | 11 |
| Completed | 17 | 9 | 11 |
| Not completed | 0 | 0 | 0 |
| Milestone | ICU A Feedback First, Then no Feedback, and Feedback Last | ICU B No Feedback First, Then Feedback, and No Feedback Last | ICU C: Feedback First, Then No Feedback, and Feedback Last |
|---|---|---|---|
| Started | 11 | 8 | 5 |
| Completed | 11 | 8 | 5 |
| Not completed | 0 | 0 | 0 |
Measured as a continuous variable between 0% and 100% compliance.
| percentage of time | Feedback | No Feedback |
|---|---|---|
| Compliance to Head of Bed Elevation to 30 Degree or More. | 37.3 ± 26.2 | 32.4 ± 29.3 |
Collected over 3 months. Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Feedback | 0/49 (0%) | 0/49 (0%) | 0/49 (0%) |
| No Feedback | 0/41 (0%) | 0/41 (0%) | 0/41 (0%) |
| Age, Categorical(Participants) | Feedback | No Feedback | Total |
|---|---|---|---|
| <=18 years | 0 | 0 | 0 |
| Between 18 and 65 years | 32 | 31 | 63 |
| >=65 years | 17 | 10 | 27 |
| Age, Continuous(years) | Feedback | No Feedback | Total |
|---|---|---|---|
| Mean | 56.7 ± 12.7 | 58.7 ± 10.1 | 57.6 ± 11.6 |
| Sex: Female, Male(Participants) | Feedback | No Feedback | Total |
|---|---|---|---|
| Female | 16 | 19 | 35 |
| Male | 33 | 22 | 55 |
| Ethnicity (NIH/OMB)(Participants) | Feedback | No Feedback | Total |
|---|---|---|---|
| Hispanic or Latino | 18 | 14 | 32 |
| Not Hispanic or Latino | 31 | 27 | 58 |
| Unknown or Not Reported | 0 | 0 | 0 |
| Race (NIH/OMB)(Participants) | Feedback | No Feedback | Total |
|---|---|---|---|
| American Indian or Alaska Native | 0 | 1 | 1 |
| Asian | 1 | 0 | 1 |
| Native Hawaiian or Other Pacific Islander | 0 | 0 | 0 |
| Black or African American | 17 | 14 | 31 |
| White | 12 | 10 | 22 |
| More than one race | 0 | 0 | 0 |
| Unknown or Not Reported | 19 | 16 | 35 |
| Region of Enrollment(participants) | Feedback | No Feedback | Total |
|---|---|---|---|
| United States | 49 | 41 | 90 |
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No
Ran from Jul 2018 to primary completion in Sep 2018, 2 months.
Results were first posted in Jan 2021, 2 years 3 months after primary completion.
Of 82 interventional studies with no phase under Pneumonia, Ventilator-Associated, half reached primary completion within 20 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 36. This study's 2 months is below that.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.
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Pneumonia, Ventilator-Associated →