An interventional study of Test Essential Oil Blend and Active Essential Oil Blend in Anxiety and Autism Spectrum Disorder, sponsored by Nutraceuticals Research Institute. Withdrawn at 1 site in United States. Open to participants aged 6 Years to 11 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-11-05.
Sponsored by Nutraceuticals Research Institute · Not applicable, Interventional, and Prevention
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Among 773 studies in Autism Spectrum Disorder with a site in United States — 166 open to participants now, 205 under way, 9 of them phase 3. Autism Spectrum Disorder · United States.
Among the 773 studies in Autism Spectrum Disorder with a site in United States, this one is the 639th largest by enrollment of the 658 interventional ones that give a count, is one of 60 that started in 2019, is one of 456 with no phase, and was the 301st registered.
1,726 studies on the registry are indexed under Autism Spectrum Disorder; 501 are open to participants now.
Browse Autism Spectrum Disorder studies →166 of the 773 studies in Autism Spectrum Disorder with a site in United States are open now. Recruiting first, the newest first:
Massachusetts General Hospital · Sites in United States
Ages 12–17
Schweitzer Engineering Laboratories · Sites in United States
Ages 24 mo–60 mo · Healthy volunteers
Children's Hospital Medical Center, Cincinnati · Sites in United States
Ages 12–18
Bristol-Myers Squibb · Sites in United States, Australia, Canada and 1 more country
Ages 5–17
Bristol-Myers Squibb · Sites in United States, France, Germany and 7 more countries
Ages 5–17
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 350 Autism Spectrum Disorder studies recruiting now, 48 (14%) set no upper age limit and 295 (84%) stop at 75 or younger; 298 take children under 18; 92 take healthy volunteers.
This study: 6 Years to 11 Years · all sexes · healthy volunteers too.
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773 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 52 · Phase 2 117 · Phase 3 33 · Phase 4 16
First in 2004; this study’s year is marked. 60 started in 2019.
By drug class, each counting the studies that test any of its medicines:
Median enrollment 50 across the 658 interventional studies, 132 across the 114 observational. Of the 521 that completed or were terminated, 174 (33%) have results posted.
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89 of 773 have an industry lead sponsor. The 10 most frequent:
Nutraceuticals Research Institute is the lead sponsor of 22 studies on the registry; 3 are open to participants now.
Nutraceuticals Research Institute has 2 studies filed under Autism Spectrum Disorder — fewer than ten, so there is no comparison to draw.
68 of the studies in Autism Spectrum Disorder with a site in United States that are under way reach primary completion within a year, 2 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06706674Phase 3Intra-Cellular Therapies, Inc.Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder (ASD) in Pediatric Patients | 2027-06-21 |
| NCT06690398Phase 3Intra-Cellular Therapies, Inc.Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder in Pediatric Patients | 2027-06-21 |
| NCT07670000Natalia PoluektovaMental And Speech Developmental Delay Autism Spectrum-Type Behavioral Disorder | 2026-11 |
| NCT04242355Yale UniversityTranscranial Magnetic Stimulation on Neural and Behavioral Facets of Social Cognition in Autism Spectrum Disorder | 2026-12 |
| NCT06059352Loma Linda UniversitySleep and Central Auditory Processing Disorder in Autism Spectrum Disorder | 2026-12 |
Add all 68 to your calendar (.ics) → With an account.
Among the 773 studies in Autism Spectrum Disorder with a site in United States, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This study evaluates the effects of essential oils on anxiety scores among children who have an autism spectrum disorder. One third of the children will receive a control blend of oils, one third of the children will receive a test blend of oils, and the other third will receive a second test blend of oils.
Essential oils have been found in studies to reduce both stress and anxiety as measured by an anxiety inventory, but studies have not tested these effects among children who have an autism spectrum disorder.
The essential oils used in this study are administered each morning for a total period of four weeks, with an optional second exposure on an as-needed basis during the final two of the four weeks of the study. The oils are administered during this time to evaluate both the preventive effects and the treatment effects of the essential oils.
Anxiety is measured on an anxiety inventory, which is completed by the parent of the participant at the end of each week during the study. Parents complete this data online, allowing them to participate from anywhere in the U.S.
1,726 studies on the registry are indexed under Autism Spectrum Disorder; 501 are open to participants now.
Browse Autism Spectrum Disorder studies →Nutraceuticals Research Institute is the lead sponsor of 22 studies on the registry; 3 are open to participants now.
Compared within Autism Spectrum Disorder, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Anxiety Disorders. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants in this arm receive the test essential oil inhaler to administer during the 4-week intervention.
Other: Test Essential Oil Blend
Participants in this arm receive an active essential oil inhaler to administer during the 4-week intervention.
Other: Active Essential Oil Blend
Participants in this arm receive a control inhaler to administer during the 4-week intervention.
Other: Control Blend
The test essential oil blend consists of plant derived oils which have been distilled from crude plant matter and analyzed in a laboratory to identify chemical composition.
The active essential oil blend consists of plant derived oils which have been distilled from crude plant matter and analyzed in a laboratory to identify chemical composition.
The control blend consists of inert vegetable oils which are produced from plant matter.
39-Question Spence Children's Anxiety Scale (SCAS)
The Spence Children's Anxiety Scale collects parent-reported signs and symptoms of anxiety at baseline and again at the end of each week of the intervention. Each item is scored as (0) never, (1) sometimes (2) often, or (3)always. The total score ranges from 0-114, with higher scores indicating higher levels of anxiety.
Time frame: baseline and day 35
Plan to share: No — Data will not be shared.
No publications or documents are linked to this record.
Ran from Jul 2019 to primary completion in Aug 2021, 25 months.
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This study is withdrawn, as verified in Oct 2021. You cannot join it, but the record below documents what was studied.
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Nutraceuticals Research Institute