An interventional study of immunoblot in Wheat Allergy, Anaphylaxis Food and Anaphylaxis Exercise, sponsored by Mahidol University. Completed at 1 site in Thailand. Open to participants aged 1 Year to 60 Years. Per ClinicalTrials.gov, last updated 2018-04-04.
Sponsored by Mahidol University · Not applicable, Interventional, and Diagnostic
Wheat is one of the most common causes in food-induced anaphylaxis and food dependent, exercised induced anaphylaxis. Gold standard for diagnose food allergy is double blind placebo control food challenge, but it is a high risk procedure. The accuracy of skin prick test and specific IgE assay showed unsatisfactory results. It might be explained by these tests may not detect all of the major allergens in wheat allergic patients. Previous studies showed that the major allergens of wheat dependent, exercised induced anaphylaxis are omega5 gliadin, followed by high molecular weight glutenin. For IgE-mediated wheat allergy, the major allergens varied among studies, including omega5 gliadin, glutenin, alpha/beta/gamma gliadin, and the water-soluble part of wheat allergens. There is no study to direct compare the major allergen between patients who have low wheat specific IgE and very high wheat specific IgE. Also, there is no data about the major allergens of wheat anaphylaxis in Thai population.
20 studies on the registry are indexed under Wheat Hypersensitivity; 5 are open to participants now.
This study's enrollment of 36 is below the median of 46 across 14 interventional studies indexed under Wheat Hypersensitivity.
Browse Wheat Hypersensitivity studies →Mahidol University is the lead sponsor of 747 studies on the registry; 119 are open to participants now.
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A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Different level of specific IgE and immunoblot
Diagnostic Test: immunoblot
immunoblot
Major allergen sensitized by Thai Patients with Wheat anaphylaxis
To Identify major allergen (most component of protein that cause wheat allergy) between wheat anaphylaxis (low Specific IgE and high Specific IgE) and wheat dependent, exercise induced anaphylaxis by using immunoblot method (Electrophoresis). The results will be shown in electrophoresis gel and can identify in molecular weight (KDa) of protein which represent to major allergen of wheat protein.
Time frame: 1 hour
This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
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